FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117324900> ?p ?o ?g. }

• W2117324900 abstract "Background Alzheimer’s disease (AD) is the most common form of dementia. The incidence of AD rises exponentially with age and its prevalence will increase significantly worldwide in the next few decades. Inflammatory processes have been suspected in the pathogenesis of the disease. Objectives To review the efficacy and side effects of aspirin, steroidal and non‐steroidal anti‐inflammatory drugs (NSAIDs) in the treatment of AD, compared to placebo. Search methods We searched ALOIS: the Cochrane Dementia and Cognitive Improvement Group’s Specialized Register on 12 April 2011 using the terms: aspirin OR cyclooxygenase 2 inhibitor OR aceclofenac OR acemetacin OR betamethasone OR celecoxib OR cortisone OR deflazacort OR dexamethasone OR dexibruprofen OR dexketoprofen OR diclofenac sodium OR diflunisal OR diflusinal OR etodolac OR etoricoxib OR fenbufen OR fenoprofen OR flurbiprofen OR hydrocortisone OR ibuprofen OR indometacin OR indomethacin OR ketoprofen OR lumiracoxib OR mefenamic OR meloxicam OR methylprednisolone OR nabumetone OR naproxen OR nimesulide OR anti‐inflammatory OR prednisone OR piroxicam OR sulindac OR tenoxicam OR tiaprofenic acid OR triamcinolone OR NSAIDS OR NSAID. ALOIS contains records of clinical trials identified from monthly searches of a number of major healthcare databases (including MEDLINE, EMBASE, PsycINFO, CINAHL, LILACS), numerous trial registries (including national, international and pharmacuetical registries) and grey literature sources. Selection criteria All randomised controlled trials assessing the efficacy of aspirin, steroidal and non‐steroidal anti‐inflammatory drugs in AD. Data collection and analysis One author assessed risk of bias of each study and extracted data. A second author verified data selection. Main results Our search identified 604 potentially relevant studies. Of these, 14 studies (15 interventions) were RCTs and met our inclusion criteria. The numbers of participants were 352, 138 and 1745 for aspirin, steroid and NSAIDs groups, respectively. One selected study comprised two separate interventions. Interventions assessed in these studies were grouped into four categories: aspirin (three interventions), steroids (one intervention), traditional NSAIDs (six interventions), and selective cyclooxygenase‐2 (COX‐2) inhibitors (five interventions). All studies were evaluated for internal validity using a risk of bias assessment tool. The risk of bias was low for five studies, high for seven studies, and unclear for two studies.There was no significant improvement in cognitive decline for aspirin, steroid, traditional NSAIDs and selective COX‐2 inhibitors. Compared to controls, patients receiving aspirin experienced more bleeding while patients receiving steroid experienced more hyperglycaemia, abnormal lab results and face edema. Patients receiving NSAIDs experienced nausea, vomiting, elevated creatinine, elevated LFT and hypertension. A trend towards higher death rates was observed among patients treated with NSAIDS compared with placebo and this was somewhat higher for selective COX‐2 inhibitors than for traditional NSAIDs. Authors' conclusions Based on the studies carried out so far, the efficacy of aspirin, steroid and NSAIDs (traditional NSAIDs and COX‐2 inhibitors) is not proven. Therefore, these drugs cannot be recommended for the treatment of AD." @default.
• W2117324900 created "2016-06-24" @default.
• W2117324900 creator A5013039097 @default.
• W2117324900 creator A5020181143 @default.
• W2117324900 creator A5056395692 @default.
• W2117324900 creator A5072967819 @default.
• W2117324900 date "2012-02-15" @default.
• W2117324900 modified "2023-10-10" @default.
• W2117324900 title "Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease" @default.
• W2117324900 cites W131585736 @default.
• W2117324900 cites W1500175872 @default.
• W2117324900 cites W1578837987 @default.
• W2117324900 cites W1583233660 @default.
• W2117324900 cites W1607135210 @default.
• W2117324900 cites W1866094682 @default.
• W2117324900 cites W1963810383 @default.
• W2117324900 cites W1964533656 @default.
• W2117324900 cites W1966012148 @default.
• W2117324900 cites W1967583546 @default.
• W2117324900 cites W1969078168 @default.
• W2117324900 cites W1974305753 @default.
• W2117324900 cites W1975171053 @default.
• W2117324900 cites W1980574540 @default.
• W2117324900 cites W1981962503 @default.
• W2117324900 cites W1982499883 @default.
• W2117324900 cites W1982658190 @default.
• W2117324900 cites W1982816514 @default.
• W2117324900 cites W1983258883 @default.
• W2117324900 cites W1984404080 @default.
• W2117324900 cites W1987826243 @default.
• W2117324900 cites W1987970630 @default.
• W2117324900 cites W1990118308 @default.
• W2117324900 cites W1992176243 @default.
• W2117324900 cites W1992318681 @default.
• W2117324900 cites W1995175521 @default.
• W2117324900 cites W1996179074 @default.
• W2117324900 cites W2004264274 @default.
• W2117324900 cites W2007911264 @default.
• W2117324900 cites W2008622181 @default.
• W2117324900 cites W2009178440 @default.
• W2117324900 cites W2010899039 @default.
• W2117324900 cites W2014207161 @default.
• W2117324900 cites W2014577085 @default.
• W2117324900 cites W2018962529 @default.
• W2117324900 cites W2020239320 @default.
• W2117324900 cites W2020662551 @default.
• W2117324900 cites W2026281867 @default.
• W2117324900 cites W2026650249 @default.
• W2117324900 cites W2030043933 @default.
• W2117324900 cites W2032161093 @default.
• W2117324900 cites W2033006731 @default.
• W2117324900 cites W2034561307 @default.
• W2117324900 cites W2035944548 @default.
• W2117324900 cites W2036244787 @default.
• W2117324900 cites W2036821168 @default.
• W2117324900 cites W2037099926 @default.
• W2117324900 cites W2037257132 @default.
• W2117324900 cites W2038496414 @default.
• W2117324900 cites W2039453997 @default.
• W2117324900 cites W2041355017 @default.
• W2117324900 cites W2042706422 @default.
• W2117324900 cites W2042947817 @default.
• W2117324900 cites W2043679754 @default.
• W2117324900 cites W2044975042 @default.
• W2117324900 cites W2046454316 @default.
• W2117324900 cites W2046746362 @default.
• W2117324900 cites W2047511834 @default.
• W2117324900 cites W2047704857 @default.
• W2117324900 cites W2048895475 @default.
• W2117324900 cites W2049011501 @default.
• W2117324900 cites W2049690653 @default.
• W2117324900 cites W2049985837 @default.
• W2117324900 cites W2050788689 @default.
• W2117324900 cites W2051118933 @default.
• W2117324900 cites W2051776695 @default.
• W2117324900 cites W2053122286 @default.
• W2117324900 cites W2053223105 @default.
• W2117324900 cites W2056014943 @default.
• W2117324900 cites W2059629926 @default.
• W2117324900 cites W2059800235 @default.
• W2117324900 cites W2061314718 @default.
• W2117324900 cites W2061333828 @default.
• W2117324900 cites W2063086502 @default.
• W2117324900 cites W2068228829 @default.
• W2117324900 cites W2068477037 @default.
• W2117324900 cites W2068932980 @default.
• W2117324900 cites W2072242488 @default.
• W2117324900 cites W2079725819 @default.
• W2117324900 cites W2083556882 @default.
• W2117324900 cites W2084808158 @default.
• W2117324900 cites W2087123644 @default.
• W2117324900 cites W2088383907 @default.
• W2117324900 cites W2089808957 @default.
• W2117324900 cites W2090150925 @default.
• W2117324900 cites W2091628499 @default.
• W2117324900 cites W2096878963 @default.
• W2117324900 cites W2109891655 @default.
• W2117324900 cites W2109982376 @default.
• W2117324900 cites W2110585971 @default.
• W2117324900 cites W2113639766 @default.

• next