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• W2117327462 abstract "Inhibitory G (Gi) proteins have been proposed to be cardioprotective. We investigated effects of Gαi2 knockout on cardiac function and survival in a murine heart failure model of cardiac β1-adrenoceptor overexpression. β1-transgenic mice lacking Gαi2 (β1-tg/Gαi2−/−) were compared with wild-type mice and littermates either overexpressing cardiac β1-adrenoceptors (β1-tg) or lacking Gαi2 (Gαi2−/−). At 300 days, mortality of mice only lacking Gαi2 was already higher compared with wild-type or β1-tg, but similar to β1-tg/Gαi2−/−, mice. Beyond 300 days, mortality of β1-tg/Gαi2−/− mice was enhanced compared with all other genotypes (mean survival time: 363 ± 21 days). At 300 days of age, echocardiography revealed similar cardiac function of wild-type, β1-tg, and Gαi2−/− mice, but significant impairment for β1-tg/Gαi2−/− mice (e.g. ejection fraction 14 ± 2 vs. 40 ± 4% in wild-type mice). Significantly increased ventricle-to-body weight ratio (0.71 ± 0.06 vs. 0.48 ± 0.02% in wild-type mice), left ventricular size (length 0.82 ± 0.04 vs. 0.66 ± 0.03 cm in wild types), and atrial natriuretic peptide and brain natriuretic peptide expression (mRNA: 2819 and 495% of wild-type mice, respectively) indicated hypertrophy. Gαi3 was significantly up-regulated in Gαi2 knockout mice (protein compared with wild type: 340 ± 90% in Gαi2−/− and 394 ± 80% in β1-tg/Gαi2−/−, respectively). Gαi2 deficiency combined with cardiac β1-adrenoceptor overexpression strongly impaired survival and cardiac function. At 300 days of age, β1-adrenoceptor overexpression alone had not induced cardiac hypertrophy or dysfunction while there was overt cardiomyopathy in mice additionally lacking Gαi2. We propose an enhanced effect of increased β1-adrenergic drive by the lack of protection via Gαi2. Gαi3 up-regulation was not sufficient to compensate for Gαi2 deficiency, suggesting an isoform-specific or a concentration-dependent mechanism." @default.
• W2117327462 created "2016-06-24" @default.
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• W2117327462 date "2015-10-13" @default.
• W2117327462 modified "2023-10-17" @default.
• W2117327462 title "Lack of Gα_i2leads to dilative cardiomyopathy and increased mortality in β₁-adrenoceptor overexpressing mice" @default.
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• W2117327462 doi "https://doi.org/10.1093/cvr/cvv235" @default.
• W2117327462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4648201" @default.
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• W2117327462 hasPublicationYear "2015" @default.
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