Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117328613> ?p ?o ?g. }
- W2117328613 endingPage "442" @default.
- W2117328613 startingPage "432" @default.
- W2117328613 abstract "Surgically resecting liver metastases from colorectal cancer (CLMs) offers the only potentially curative option. Chemotherapy-induced downsizing of CLMs increases the proportion of patients with resectable metastases. Several recent studies have reported that adding a biological agent such as cetuximab, panitumumab or bevacizumab to chemotherapy could further increase response and resectability rates. This overview discusses the reported resection rates for biological agents combined with chemotherapy and the difficulties of cross-trial comparisons, the pre-, peri- and postoperative roles of biological agents, particularly with regards to comparisons of surgical complications, and ongoing clinical trials in which the resectability of CLMs is a predefined end point. Currently, targeted therapies combined with chemotherapy probably increase the resection rate of CLMs, although this has been shown in only one phase III randomised study and it is difficult to draw definitive conclusions about the relative efficacy and safety of the different available biological agents in terms of converting unresectable CLMs to resectable lesions. Available data for each of them are discussed. More data from phase III trials are expected to confirm the utility of the different biological agents in converting patients with unresectable CLMs to a resectable status." @default.
- W2117328613 created "2016-06-24" @default.
- W2117328613 creator A5008173055 @default.
- W2117328613 creator A5012325306 @default.
- W2117328613 creator A5015232096 @default.
- W2117328613 creator A5024946017 @default.
- W2117328613 creator A5025262073 @default.
- W2117328613 date "2012-08-01" @default.
- W2117328613 modified "2023-10-18" @default.
- W2117328613 title "The Role of Biological Agents in the Resection of Colorectal Liver Metastases" @default.
- W2117328613 cites W17456534 @default.
- W2117328613 cites W1761315808 @default.
- W2117328613 cites W1966703018 @default.
- W2117328613 cites W1970844261 @default.
- W2117328613 cites W1974913186 @default.
- W2117328613 cites W1975661080 @default.
- W2117328613 cites W1976550982 @default.
- W2117328613 cites W1980005697 @default.
- W2117328613 cites W1982434374 @default.
- W2117328613 cites W1989175303 @default.
- W2117328613 cites W2008306871 @default.
- W2117328613 cites W2008519330 @default.
- W2117328613 cites W2015155974 @default.
- W2117328613 cites W2015223642 @default.
- W2117328613 cites W2026662149 @default.
- W2117328613 cites W2027449064 @default.
- W2117328613 cites W2033597946 @default.
- W2117328613 cites W2033734921 @default.
- W2117328613 cites W2035454562 @default.
- W2117328613 cites W2039444733 @default.
- W2117328613 cites W2039652475 @default.
- W2117328613 cites W2045566529 @default.
- W2117328613 cites W2049036294 @default.
- W2117328613 cites W2058242433 @default.
- W2117328613 cites W2061750787 @default.
- W2117328613 cites W2064035676 @default.
- W2117328613 cites W2066040529 @default.
- W2117328613 cites W2067482493 @default.
- W2117328613 cites W2075657558 @default.
- W2117328613 cites W2084954217 @default.
- W2117328613 cites W2090325319 @default.
- W2117328613 cites W2095201384 @default.
- W2117328613 cites W2097644228 @default.
- W2117328613 cites W2099036520 @default.
- W2117328613 cites W2110915643 @default.
- W2117328613 cites W2112491858 @default.
- W2117328613 cites W2118768896 @default.
- W2117328613 cites W2119943104 @default.
- W2117328613 cites W2121327919 @default.
- W2117328613 cites W2122685638 @default.
- W2117328613 cites W2124160356 @default.
- W2117328613 cites W2125857654 @default.
- W2117328613 cites W2125877119 @default.
- W2117328613 cites W2128628626 @default.
- W2117328613 cites W2131745440 @default.
- W2117328613 cites W2134920919 @default.
- W2117328613 cites W2138235363 @default.
- W2117328613 cites W2139119404 @default.
- W2117328613 cites W2143743735 @default.
- W2117328613 cites W2144425748 @default.
- W2117328613 cites W2144727645 @default.
- W2117328613 cites W2148053260 @default.
- W2117328613 cites W2151062573 @default.
- W2117328613 cites W2154414933 @default.
- W2117328613 cites W2157769714 @default.
- W2117328613 cites W2158918006 @default.
- W2117328613 cites W2162102504 @default.
- W2117328613 cites W2164194457 @default.
- W2117328613 cites W2164799457 @default.
- W2117328613 cites W2165388519 @default.
- W2117328613 cites W2165741055 @default.
- W2117328613 cites W2167422856 @default.
- W2117328613 cites W2168460655 @default.
- W2117328613 cites W2186944346 @default.
- W2117328613 cites W2223105341 @default.
- W2117328613 cites W2241118977 @default.
- W2117328613 cites W2248034498 @default.
- W2117328613 cites W2248542131 @default.
- W2117328613 cites W2268418975 @default.
- W2117328613 cites W2287509987 @default.
- W2117328613 cites W2288085092 @default.
- W2117328613 cites W2303876367 @default.
- W2117328613 cites W2338874213 @default.
- W2117328613 cites W2968292138 @default.
- W2117328613 doi "https://doi.org/10.1016/j.clon.2012.01.002" @default.
- W2117328613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22794325" @default.
- W2117328613 hasPublicationYear "2012" @default.
- W2117328613 type Work @default.
- W2117328613 sameAs 2117328613 @default.
- W2117328613 citedByCount "10" @default.
- W2117328613 countsByYear W21173286132013 @default.
- W2117328613 countsByYear W21173286132014 @default.
- W2117328613 countsByYear W21173286132015 @default.
- W2117328613 countsByYear W21173286132016 @default.
- W2117328613 countsByYear W21173286132017 @default.
- W2117328613 countsByYear W21173286132018 @default.
- W2117328613 crossrefType "journal-article" @default.
- W2117328613 hasAuthorship W2117328613A5008173055 @default.