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• W2117367044 abstract "While T cell-based vaccines have the potential to provide protection against chronic virus infections, they also have the potential to generate immunopathology following subsequent virus infection. We develop a mathematical model to investigate the conditions under which T cells lead to protection versus adverse pathology. The model illustrates how the balance between virus clearance and immune exhaustion may be disrupted when vaccination generates intermediate numbers of specific CD8 T cells. Surprisingly, our model suggests that this adverse effect of vaccination is largely unaffected by the generation of mutant viruses that evade T cell recognition and cannot be avoided by simply increasing the quality (affinity) or diversity of the T cell response. These findings should be taken into account when developing vaccines against persistent infections." @default.
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• W2117367044 date "2011-06-01" @default.
• W2117367044 modified "2023-09-25" @default.
• W2117367044 title "Vaccination Alters the Balance between Protective Immunity, Exhaustion, Escape, and Death in Chronic Infections" @default.
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• W2117367044 doi "https://doi.org/10.1128/jvi.00166-11" @default.
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