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• W2117372008 abstract "El lopinavir/ritonavir (LPV/r) ha demostrado eficacia virológica e inmunológica en el tratamiento antirretroviral (TAR) combinado, tanto en pacientes naïve como pretratados. Además presenta una alta barrera genética al desarrollo de resistencias y su perfil de tolerancia es aceptable, aunque son frecuentes alteraciones gastrointestinales y del perfil lipídico. Se revisan diferentes estrategias utilizadas en la optimización del TAR con este fármaco en la práctica clínica diaria, haciendo especial incidencia en la monitorización de concentraciones plasmáticas de LPV/r y la caracterización farmacogenética de las principales isoenzimas responsables de su metabolismo y transporte. En este sentido, la correlación del genotipo con el fenotipo establecida en la monitorización de niveles de LPV/r facilitaría la individualización posológica de los tratamientos con este fármaco. Así mismo, se revisa la estrategia de simplificación del tratamiento a monoterapia, lo que permitiría incrementar la seguridad y disminuir los costes. Lopinavir/ritonavir (LPV/r) has demonstrated virological and immunological efficacy in the combined antiretroviral treatment (cART), in both naïve and experienced patients. Furthermore, LPV/r showed a high barrier to the development of resistance. Although generally well tolerated, adverse gastrointestinal side effects and metabolic disorders are frequent. The different tools used to optimise the cART with this drug combination in the daily clinical practice, emphasising the therapeutic drug monitoring (TDM) of LPV/r and the genetic analysis of the main enzymes responsible for the metabolism and transport, are reviewed. The relationship between phenotype and genotype, established through TDM, could be useful for the physician to improve the clinical management of the HIV infection, due to the possibility of individualising the dose with this drug. Monotherapy is also reviewed as a new strategy used in the simplification of the treatment with this drug, which could increase safety and reduce costs." @default.
• W2117372008 created "2016-06-24" @default.
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• W2117372008 date "2013-01-01" @default.
• W2117372008 modified "2023-10-03" @default.
• W2117372008 title "Nuevas estrategias en la optimización posológica de lopinavir/ritonavir en pacientes infectados por el virus de la inmunodeficiencia humana" @default.
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• W2117372008 doi "https://doi.org/10.1016/j.eimc.2011.11.018" @default.
• W2117372008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22280562" @default.
• W2117372008 hasPublicationYear "2013" @default.
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