FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117392783> ?p ?o ?g. }

• W2117392783 endingPage "e74907" @default.
• W2117392783 startingPage "e74907" @default.
• W2117392783 abstract "MicroRNAs (miRNAs) are evolutionarily conserved non-coding RNAs of ∼22 nucleotides that regulate gene expression at the level of translation and play vital roles in hippocampal neuron development, function and plasticity. Here, we performed a systematic and in-depth analysis of miRNA expression profiles in cultured hippocampal neurons during development and after induction of neuronal activity. MiRNA profiling of primary hippocampal cultures was carried out using locked nucleic-acid-based miRNA arrays. The expression of 264 different miRNAs was tested in young neurons, at various developmental stages (stage 2-4) and in mature fully differentiated neurons (stage 5) following the induction of neuronal activity using chemical stimulation protocols. We identified 210 miRNAs in mature hippocampal neurons; the expression of most neuronal miRNAs is low at early stages of development and steadily increases during neuronal differentiation. We found a specific subset of 14 miRNAs with reduced expression at stage 3 and showed that sustained expression of these miRNAs stimulates axonal outgrowth. Expression profiling following induction of neuronal activity demonstrates that 51 miRNAs, including miR-134, miR-146, miR-181, miR-185, miR-191 and miR-200a show altered patterns of expression after NMDA receptor-dependent plasticity, and 31 miRNAs, including miR-107, miR-134, miR-470 and miR-546 were upregulated by homeostatic plasticity protocols. Our results indicate that specific miRNA expression profiles correlate with changes in neuronal development and neuronal activity. Identification and characterization of miRNA targets may further elucidate translational control mechanisms involved in hippocampal development, differentiation and activity-depended processes." @default.
• W2117392783 created "2016-06-24" @default.
• W2117392783 creator A5001753652 @default.
• W2117392783 creator A5010209043 @default.
• W2117392783 creator A5017819340 @default.
• W2117392783 creator A5019567999 @default.
• W2117392783 creator A5048330851 @default.
• W2117392783 creator A5054087192 @default.
• W2117392783 creator A5058356091 @default.
• W2117392783 creator A5058880522 @default.
• W2117392783 creator A5064421447 @default.
• W2117392783 creator A5085813010 @default.
• W2117392783 creator A5088514186 @default.
• W2117392783 date "2013-10-03" @default.
• W2117392783 modified "2023-10-16" @default.
• W2117392783 title "Developmental and Activity-Dependent miRNA Expression Profiling in Primary Hippocampal Neuron Cultures" @default.
• W2117392783 cites W1526729571 @default.
• W2117392783 cites W1557933310 @default.
• W2117392783 cites W1895213472 @default.
• W2117392783 cites W1943992675 @default.
• W2117392783 cites W1965115912 @default.
• W2117392783 cites W1968300632 @default.
• W2117392783 cites W1969132788 @default.
• W2117392783 cites W1972931349 @default.
• W2117392783 cites W1976984383 @default.
• W2117392783 cites W1978337436 @default.
• W2117392783 cites W1978922003 @default.
• W2117392783 cites W1979261061 @default.
• W2117392783 cites W1983949013 @default.
• W2117392783 cites W1985498551 @default.
• W2117392783 cites W1986005801 @default.
• W2117392783 cites W1991818527 @default.
• W2117392783 cites W1992086750 @default.
• W2117392783 cites W1995058183 @default.
• W2117392783 cites W1996833338 @default.
• W2117392783 cites W1998117752 @default.
• W2117392783 cites W1999425454 @default.
• W2117392783 cites W2000430854 @default.
• W2117392783 cites W2000874341 @default.
• W2117392783 cites W2002734542 @default.
• W2117392783 cites W2006169630 @default.
• W2117392783 cites W2006767450 @default.
• W2117392783 cites W2015205234 @default.
• W2117392783 cites W2015858554 @default.
• W2117392783 cites W2016390086 @default.
• W2117392783 cites W2021387967 @default.
• W2117392783 cites W2021901721 @default.
• W2117392783 cites W2026686516 @default.
• W2117392783 cites W2027436298 @default.
• W2117392783 cites W2027873044 @default.
• W2117392783 cites W2035082265 @default.
• W2117392783 cites W2035584918 @default.
• W2117392783 cites W2035891650 @default.
• W2117392783 cites W2039959072 @default.
• W2117392783 cites W2041102021 @default.
• W2117392783 cites W2041188364 @default.
• W2117392783 cites W2041458184 @default.
• W2117392783 cites W2041945875 @default.
• W2117392783 cites W2043965906 @default.
• W2117392783 cites W2050066016 @default.
• W2117392783 cites W2052536256 @default.
• W2117392783 cites W2052677441 @default.
• W2117392783 cites W2053582732 @default.
• W2117392783 cites W2060317992 @default.
• W2117392783 cites W2060333697 @default.
• W2117392783 cites W2060578299 @default.
• W2117392783 cites W2061414672 @default.
• W2117392783 cites W2061463538 @default.
• W2117392783 cites W2065677411 @default.
• W2117392783 cites W2068435160 @default.
• W2117392783 cites W2070571588 @default.
• W2117392783 cites W2071013424 @default.
• W2117392783 cites W2071474610 @default.
• W2117392783 cites W2071925802 @default.
• W2117392783 cites W2072810552 @default.
• W2117392783 cites W2078047436 @default.
• W2117392783 cites W2085103168 @default.
• W2117392783 cites W2088415316 @default.
• W2117392783 cites W2088762048 @default.
• W2117392783 cites W2089084448 @default.
• W2117392783 cites W2089278672 @default.
• W2117392783 cites W2090183355 @default.
• W2117392783 cites W2092083785 @default.
• W2117392783 cites W2100358595 @default.
• W2117392783 cites W2102406841 @default.
• W2117392783 cites W2105989397 @default.
• W2117392783 cites W2107139283 @default.
• W2117392783 cites W2109208582 @default.
• W2117392783 cites W2110043783 @default.
• W2117392783 cites W2116641097 @default.
• W2117392783 cites W2117391623 @default.
• W2117392783 cites W2118176338 @default.
• W2117392783 cites W2120821369 @default.
• W2117392783 cites W2123628900 @default.
• W2117392783 cites W2124486266 @default.
• W2117392783 cites W2127202058 @default.
• W2117392783 cites W2127560698 @default.
• W2117392783 cites W2128834282 @default.

• next