Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117396802> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2117396802 endingPage "2642" @default.
- W2117396802 startingPage "2636" @default.
- W2117396802 abstract "We have shown previously that an IgM mAb (A10) recognizing Ehrlich tumor (ET) cell surface carbohydrates, inhibits in vivo ET growth by a macrophage-dependent mechanism. The inhibition mechanism involving both IgM and macrophages was unclear because receptors for IgM on macrophages are controversial and another monoclonal IgM (E1), also recognizing ET cell surface carbohydrates, was completely unable to show any protective effect. Here we show that A10, but not E1, was able to promote adhesion between macrophages and ET cells by a receptor for IgM-independent mechanism. Immunofluorescence studies showed that A10, but not E1, did react with macrophages if these cells were preincubated with a source of Ag spontaneously released from ET cells. This Ag release appeared to be required for A10-mediated adhesion, because adhesion was not obtained when ET cells fixed with paraformaldehyde were used. Cytostasis studies performed with macrophages stimulated with L-929 conditioned medium and ET cells showed that A10, but not E1 nor unrelated IgM, was able to inhibit ET cell proliferation in vitro by a mechanism involving cell contact between both cell populations. Therefore, IgM inhibition of ET growth, both in vivo and in vitro, could be explained by a lectin-like mechanism, where IgM, recognizing Ag of tumor origin, bridges macrophages to tumor cells." @default.
- W2117396802 created "2016-06-24" @default.
- W2117396802 creator A5013687669 @default.
- W2117396802 creator A5031622334 @default.
- W2117396802 creator A5031995017 @default.
- W2117396802 creator A5044711362 @default.
- W2117396802 creator A5054039508 @default.
- W2117396802 creator A5079017882 @default.
- W2117396802 date "1992-04-15" @default.
- W2117396802 modified "2023-10-17" @default.
- W2117396802 title "Tumor cytostasis mediated by a monoclonal IgM antibody promoting adhesion between macrophages and tumor cells. Evidence for a lectin-like behavior." @default.
- W2117396802 doi "https://doi.org/10.4049/jimmunol.148.8.2636" @default.
- W2117396802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1560214" @default.
- W2117396802 hasPublicationYear "1992" @default.
- W2117396802 type Work @default.
- W2117396802 sameAs 2117396802 @default.
- W2117396802 citedByCount "5" @default.
- W2117396802 crossrefType "journal-article" @default.
- W2117396802 hasAuthorship W2117396802A5013687669 @default.
- W2117396802 hasAuthorship W2117396802A5031622334 @default.
- W2117396802 hasAuthorship W2117396802A5031995017 @default.
- W2117396802 hasAuthorship W2117396802A5044711362 @default.
- W2117396802 hasAuthorship W2117396802A5054039508 @default.
- W2117396802 hasAuthorship W2117396802A5079017882 @default.
- W2117396802 hasBestOaLocation W21173968021 @default.
- W2117396802 hasConcept C109316439 @default.
- W2117396802 hasConcept C1491633281 @default.
- W2117396802 hasConcept C150903083 @default.
- W2117396802 hasConcept C153911025 @default.
- W2117396802 hasConcept C159654299 @default.
- W2117396802 hasConcept C178790620 @default.
- W2117396802 hasConcept C182547069 @default.
- W2117396802 hasConcept C185592680 @default.
- W2117396802 hasConcept C202751555 @default.
- W2117396802 hasConcept C203014093 @default.
- W2117396802 hasConcept C207001950 @default.
- W2117396802 hasConcept C2779244956 @default.
- W2117396802 hasConcept C2780758401 @default.
- W2117396802 hasConcept C542903549 @default.
- W2117396802 hasConcept C55493867 @default.
- W2117396802 hasConcept C84416704 @default.
- W2117396802 hasConcept C85789140 @default.
- W2117396802 hasConcept C86803240 @default.
- W2117396802 hasConcept C95444343 @default.
- W2117396802 hasConceptScore W2117396802C109316439 @default.
- W2117396802 hasConceptScore W2117396802C1491633281 @default.
- W2117396802 hasConceptScore W2117396802C150903083 @default.
- W2117396802 hasConceptScore W2117396802C153911025 @default.
- W2117396802 hasConceptScore W2117396802C159654299 @default.
- W2117396802 hasConceptScore W2117396802C178790620 @default.
- W2117396802 hasConceptScore W2117396802C182547069 @default.
- W2117396802 hasConceptScore W2117396802C185592680 @default.
- W2117396802 hasConceptScore W2117396802C202751555 @default.
- W2117396802 hasConceptScore W2117396802C203014093 @default.
- W2117396802 hasConceptScore W2117396802C207001950 @default.
- W2117396802 hasConceptScore W2117396802C2779244956 @default.
- W2117396802 hasConceptScore W2117396802C2780758401 @default.
- W2117396802 hasConceptScore W2117396802C542903549 @default.
- W2117396802 hasConceptScore W2117396802C55493867 @default.
- W2117396802 hasConceptScore W2117396802C84416704 @default.
- W2117396802 hasConceptScore W2117396802C85789140 @default.
- W2117396802 hasConceptScore W2117396802C86803240 @default.
- W2117396802 hasConceptScore W2117396802C95444343 @default.
- W2117396802 hasIssue "8" @default.
- W2117396802 hasLocation W21173968021 @default.
- W2117396802 hasLocation W21173968022 @default.
- W2117396802 hasOpenAccess W2117396802 @default.
- W2117396802 hasPrimaryLocation W21173968021 @default.
- W2117396802 hasRelatedWork W136700406 @default.
- W2117396802 hasRelatedWork W1825374542 @default.
- W2117396802 hasRelatedWork W1971628265 @default.
- W2117396802 hasRelatedWork W2009889818 @default.
- W2117396802 hasRelatedWork W2021117083 @default.
- W2117396802 hasRelatedWork W2067193714 @default.
- W2117396802 hasRelatedWork W2072944349 @default.
- W2117396802 hasRelatedWork W2122960395 @default.
- W2117396802 hasRelatedWork W2368460920 @default.
- W2117396802 hasRelatedWork W2380360044 @default.
- W2117396802 hasVolume "148" @default.
- W2117396802 isParatext "false" @default.
- W2117396802 isRetracted "false" @default.
- W2117396802 magId "2117396802" @default.
- W2117396802 workType "article" @default.