FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117399561> ?p ?o ?g. }

• W2117399561 endingPage "C690" @default.
• W2117399561 startingPage "C678" @default.
• W2117399561 abstract "We measured innate immune responses by primary human tracheal epithelial (HTE) cells grown as confluent, pseudostratified layers during exposure to inflammatory activators on apical vs. basolateral surfaces. Apical Pseudomonas aeruginosa strain PAK (but not flagellin mutant PAK·fliC), flagellin, and flagellin + PAK·fliC activated NF-κB and IL-8 expression and secretion. In contrast, HTE cells were insensitive to LPS compared to flagellin. Flagellin activated NF-κB in columnar but not basal cells. IL-1β + TNF-α elicited responses similar to those of flagellin. Basolateral flagellin or IL-1β + TNF-α caused 1.5- to 4-fold larger responses, consistent with the fact that NF-κB activation occurred in both columnar and basal cells. MyD88 (toll receptor-associated adapter), IL-1 receptor (IL1R)1, and TNF-α receptor (TNFR)1 were expressed in columnar and basal cells. ZO-1 was localized to tight junctions of columnar cells but not to basal cells. We infer the following. 1) Flagellin is necessary and sufficient to trigger inflammatory responses in columnar cells during accumulation of P. aeruginosa in the airway surface liquid (ASL); columnar cells express toll-like receptor 5 and MyD88, often associated with flagellin-activated cell signaling. 2) IL-1β + TNF-α in the ASL also activate columnar cells, and these cells also express IL1R1 and TNFR1. 3) Apical flagellin, IL-1β, and TNF-α do not activate basal cells because tight junctions between columnar cells prevent access from the apical surface to the basal cells. 4) Exposure of basolateral surfaces to inflammatory activators elicits larger responses because both columnar and basal cells are activated, likely because both cell types express receptors for flagellin, IL-1β, and TNF-α." @default.
• W2117399561 created "2016-06-24" @default.
• W2117399561 creator A5001904912 @default.
• W2117399561 creator A5019969647 @default.
• W2117399561 creator A5026572261 @default.
• W2117399561 creator A5060174525 @default.
• W2117399561 date "2006-03-01" @default.
• W2117399561 modified "2023-10-03" @default.
• W2117399561 title "Innate immune responses of human tracheal epithelium to<i>Pseudomonas aeruginosa</i>flagellin, TNF-α, and IL-1β" @default.
• W2117399561 cites W1519633296 @default.
• W2117399561 cites W1786185665 @default.
• W2117399561 cites W1968259615 @default.
• W2117399561 cites W1975616008 @default.
• W2117399561 cites W1983601122 @default.
• W2117399561 cites W1986449424 @default.
• W2117399561 cites W1995215609 @default.
• W2117399561 cites W2020922034 @default.
• W2117399561 cites W2029878860 @default.
• W2117399561 cites W2033532064 @default.
• W2117399561 cites W2052460623 @default.
• W2117399561 cites W2068365384 @default.
• W2117399561 cites W2070649129 @default.
• W2117399561 cites W2075328959 @default.
• W2117399561 cites W2075948284 @default.
• W2117399561 cites W2080797320 @default.
• W2117399561 cites W2085593161 @default.
• W2117399561 cites W2087765037 @default.
• W2117399561 cites W2088587327 @default.
• W2117399561 cites W2099039975 @default.
• W2117399561 cites W2112251584 @default.
• W2117399561 cites W2115082461 @default.
• W2117399561 cites W2120222530 @default.
• W2117399561 cites W2127207030 @default.
• W2117399561 cites W2130501069 @default.
• W2117399561 cites W2154013663 @default.
• W2117399561 cites W2157339124 @default.
• W2117399561 cites W2161781385 @default.
• W2117399561 cites W2173303531 @default.
• W2117399561 cites W4256529798 @default.
• W2117399561 doi "https://doi.org/10.1152/ajpcell.00166.2005" @default.
• W2117399561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16251478" @default.
• W2117399561 hasPublicationYear "2006" @default.
• W2117399561 type Work @default.
• W2117399561 sameAs 2117399561 @default.
• W2117399561 citedByCount "52" @default.
• W2117399561 countsByYear W21173995612012 @default.
• W2117399561 countsByYear W21173995612013 @default.
• W2117399561 countsByYear W21173995612014 @default.
• W2117399561 countsByYear W21173995612015 @default.
• W2117399561 countsByYear W21173995612016 @default.
• W2117399561 countsByYear W21173995612017 @default.
• W2117399561 countsByYear W21173995612019 @default.
• W2117399561 countsByYear W21173995612021 @default.
• W2117399561 countsByYear W21173995612022 @default.
• W2117399561 countsByYear W21173995612023 @default.
• W2117399561 crossrefType "journal-article" @default.
• W2117399561 hasAuthorship W2117399561A5001904912 @default.
• W2117399561 hasAuthorship W2117399561A5019969647 @default.
• W2117399561 hasAuthorship W2117399561A5026572261 @default.
• W2117399561 hasAuthorship W2117399561A5060174525 @default.
• W2117399561 hasConcept C136449434 @default.
• W2117399561 hasConcept C153911025 @default.
• W2117399561 hasConcept C170493617 @default.
• W2117399561 hasConcept C203014093 @default.
• W2117399561 hasConcept C2776709828 @default.
• W2117399561 hasConcept C38117629 @default.
• W2117399561 hasConcept C529295009 @default.
• W2117399561 hasConcept C54355233 @default.
• W2117399561 hasConcept C55493867 @default.
• W2117399561 hasConcept C86803240 @default.
• W2117399561 hasConcept C87568996 @default.
• W2117399561 hasConcept C8891405 @default.
• W2117399561 hasConcept C89423630 @default.
• W2117399561 hasConcept C95444343 @default.
• W2117399561 hasConceptScore W2117399561C136449434 @default.
• W2117399561 hasConceptScore W2117399561C153911025 @default.
• W2117399561 hasConceptScore W2117399561C170493617 @default.
• W2117399561 hasConceptScore W2117399561C203014093 @default.
• W2117399561 hasConceptScore W2117399561C2776709828 @default.
• W2117399561 hasConceptScore W2117399561C38117629 @default.
• W2117399561 hasConceptScore W2117399561C529295009 @default.
• W2117399561 hasConceptScore W2117399561C54355233 @default.
• W2117399561 hasConceptScore W2117399561C55493867 @default.
• W2117399561 hasConceptScore W2117399561C86803240 @default.
• W2117399561 hasConceptScore W2117399561C87568996 @default.
• W2117399561 hasConceptScore W2117399561C8891405 @default.
• W2117399561 hasConceptScore W2117399561C89423630 @default.
• W2117399561 hasConceptScore W2117399561C95444343 @default.
• W2117399561 hasIssue "3" @default.
• W2117399561 hasLocation W21173995611 @default.
• W2117399561 hasLocation W21173995612 @default.
• W2117399561 hasOpenAccess W2117399561 @default.
• W2117399561 hasPrimaryLocation W21173995611 @default.
• W2117399561 hasRelatedWork W1519633296 @default.
• W2117399561 hasRelatedWork W1986682458 @default.
• W2117399561 hasRelatedWork W2054083925 @default.
• W2117399561 hasRelatedWork W2084402420 @default.
• W2117399561 hasRelatedWork W2091281735 @default.

• next