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• W2117429164 abstract "Measles virus (MV) is one of the candidates for the application of oncolytic virotherapy (OVT). Although an advanced clinical study has been reported on a T-cell lymphoma, the potential of MV OVT against B-cell lymphomas remains to be clarified. We found that an EBV-transformed B lymphoblastoid cell line, a model for diffuse large B-cell lymphoma, and EBV-positive Burkitt's lymphoma cells bearing type III latency were highly susceptible to the cytolysis induced by an MV vaccine strain CAM-70. As analyzed by EBV-positive and -negative counterparts of the same cytogenetic background, type III EBV latency, not type I, was shown to augment the susceptibility of B lymphoma cells to MV-induced cytolysis. Cell surface levels of CD150/signaling lymphocytic activation molecule, a receptor of MV, were upregulated in B lymphoma cell lines with type III EBV latency by 3.8-fold, on average. The cytolytic activity of CD150-tropic WT MV was akin to that of CD46- and CD150-tropic CAM-70, suggesting that CD150 is critical for the susceptibility to MV-induced cytolysis. Among EBV-encoded genes, latent membrane protein 1 was responsible for the CD150 upregulation. It was notable that the majority of B lymphoma cell lines of type III EBV latency showed higher susceptibility to the non-Edmonston-derived CAM-70 than to the Edmonston-derived Schwarz strain. This is the first report indicating the potential of non-Edmonston MV strain for the application of OVT. Furthermore, a cellular regulator of MV replication was implicated that functions in a vaccine strain-specific fashion. Altogether, the MV OVT should serve as an alternative therapy against EBV-positive diffuse large B-cell lymphoma with type III EBV latency." @default.
• W2117429164 created "2016-06-24" @default.
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• W2117429164 date "2014-01-12" @default.
• W2117429164 modified "2023-10-16" @default.
• W2117429164 title "Enhanced susceptibility of<scp>B</scp>lymphoma cells to measles virus by<scp>E</scp>pstein–<scp>B</scp>arr virus type<scp>III</scp>latency that upregulates<scp>CD</scp>150/signaling lymphocytic activation molecule" @default.
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• W2117429164 doi "https://doi.org/10.1111/cas.12324" @default.
• W2117429164 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4317819" @default.
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