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• W2117429908 abstract "See CME exam on page 1075. See CME exam on page 1075. The American Gastroenterological Association (AGA) convened a panel of physicians in gastroenterology, rheumatology, cardiology, and internal medicine who developed this statement based on expert presentations of current scientific knowledge and through subsequent group discussion. This statement reflects the panel’s assessment of medical knowledge available when written. Thus, readers should view this statement in the context of data that invariably will accumulate after its creation. Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used medications in the world. Well-recognized gastrointestinal (GI) complications and identification of previously unrecognized cardiac risks have amplified concerns about their use. The extent of these risks varies by patient, specific agent, dosage, and concomitant medications. To increase awareness about the benefits and the risks of gastrointestinal toxicity and myocardial infarction associated with these medications and to improve the use of NSAIDs, the American Gastroenterological Association (AGA) convened a Consensus Development Conference on the Use of NSAIDs from September 30 to October 2, 2005. The Consensus Development Panel and the speakers are listed in Appendix 1 (see supplementary material online at www.cghjournal.org). This conference examined what is known about risks of myocardial infarction and gastrointestinal toxicities of these medications, their risks in specific patients, and what interventions, if any, may diminish these risks. This conference did not address specifically the known risks of kidney disease and heart failure associated with NSAID and coxib use. These risks are well described in the medical literature. Clinicians should familiarize themselves with the existing and evolving data about these risks; in addition, more information about these issues is available at www.gastro.org. During the first day of the conference, experts presented the most recent pharmacologic, clinical, and epidemiologic research about NSAIDs and their use. These presentations, summarized in Appendix 2 (see supplementary material online at www.cghjournal.org) addressed the following key questions: 1Who is at risk and what is the risk?2Who needs these medications and what are their benefits over non-NSAIDs?3Can the risk of NSAID-induced GI toxicity be modified?4Coxib risks and benefits.5Aspirin risks and benefits. After weighing this scientific evidence, the panel developed a consensus view of the gastrointestinal and cardiovascular risks of NSAIDs, and ways in which such risks may be attenuated. Lastly, the panel identified outstanding questions that warrant further study. Most health professionals are aware of the increased risk of gastrointestinal toxicity associated with NSAID use. There is less familiarity, however, with the magnitude of this risk, with risks associated with specific medications, and with ways to reduce these risks." @default.
• W2117429908 created "2016-06-24" @default.
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• W2117429908 date "2006-09-01" @default.
• W2117429908 modified "2023-10-17" @default.
• W2117429908 title "Consensus Development Conference on the Use of Nonsteroidal Anti-Inflammatory Agents, Including Cyclooxygenase-2 Enzyme Inhibitors and Aspirin" @default.
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