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- W2117443152 abstract "ABSTRACT We report our studies to probe the possible role of the host response to double-stranded RNA in cessation of alphavirus minus-strand synthesis. Mouse embryo fibroblasts (MEF) from Mx1-deficient mice that also lack either the protein kinase R (PKR) or the latent RNase L or both PKR and RNase L were screened. In RNase L-deficient but not wild-type or PKR-deficient MEF, there was continuous synthesis of minus-strand templates and the formation of new replication complexes producing viral plus strands. Inhibiting translation caused minus-strand synthesis to stop and a loss of transcription activity of the mature replication complexes. This turnover of replication complexes that were stable in cells containing RNase L suggested that RNase L plays some role, albeit possibly indirect, in the formation of stable replication complexes during alphavirus infection. In addition, confluent monolayers of RNase L-deficient murine cells readily established persistent infections and were not killed. This phenotype is contrary to what has been observed for infection in vertebrate cells with a presumably functional RNase L gene and more resembled alphavirus replication in Aedes mosquito cells, in which the activity of replication complexes making plus stands was also found to decay with inhibition of translation." @default.
- W2117443152 created "2016-06-24" @default.
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- W2117443152 creator A5047573914 @default.
- W2117443152 creator A5067358586 @default.
- W2117443152 creator A5081150848 @default.
- W2117443152 date "2003-02-01" @default.
- W2117443152 modified "2023-10-10" @default.
- W2117443152 title "Alphavirus Minus-Strand Synthesis and Persistence in Mouse Embryo Fibroblasts Derived from Mice Lacking RNase L and Protein Kinase R" @default.
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- W2117443152 doi "https://doi.org/10.1128/jvi.77.3.1801-1811.2003" @default.
- W2117443152 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/140908" @default.
- W2117443152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12525614" @default.
- W2117443152 hasPublicationYear "2003" @default.
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