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- W2117456095 abstract "From the methanolic extract of the dried roots of Saussurea lappa Clarke, Saussureae Radix, five amino acid–sesquiterpene conjugates, saussureamines A, B, C, D and E, were isolated together with a lignan glycoside, (−)-massoniresinol 4″-O-β-d-glucopyranoside. Their stereostructures were determined on the basis of chemical and physicochemical evidence. In addition, saussureamines and the related amino acid–sesquiterpene conjugates were synthesized using a Michael type addition reaction of amino acid to the α-methylene-γ-lactone moiety of sesquiterpenes. Saussureamines A, B and C, costunolide and dehydrocostus lactone showed a gastroprotective effect on acidified ethanol-induced gastric mucosal lesions in rats. Saussureamines A also exhibited an inhibitory effect on gastric mucosal lesions induced by water-immersion stress in mice." @default.
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- W2117456095 date "2000-09-01" @default.
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- W2117456095 title "Absolute Stereostructures and Syntheses of Saussureamines A, B, C, D and E, Amino Acid–Sesquiterpene Conjugates with Gastroprotective Effect, from the Roots of Saussurea lappa" @default.
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- W2117456095 doi "https://doi.org/10.1016/s0040-4020(00)00696-7" @default.
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