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• W2117476795 abstract "We uncovered the diversity of non-canonical splice sites at the human transcriptome using deep transcriptome profiling. We mapped a total of 3.7 billion human RNA-seq reads and developed a set of stringent filters to avoid false non-canonical splice site detections. We identified 184 splice sites with non-canonical dinucleotides and U2/U12-like consensus sequences. We selected 10 of the herein identified U2/U12-like non-canonical splice site events and successfully validated 9 of them via reverse transcriptase-polymerase chain reaction and Sanger sequencing. Analyses of the 184 U2/U12-like non-canonical splice sites indicate that 51% of them are not annotated in GENCODE. In addition, 28% of them are conserved in mouse and 76% are involved in alternative splicing events, some of them with tissue-specific alternative splicing patterns. Interestingly, our analysis identified some U2/U12-like non-canonical splice sites that are converted into canonical splice sites by RNA A-to-I editing. Moreover, the U2/U12-like non-canonical splice sites have a differential distribution of splicing regulatory sequences, which may contribute to their recognition and regulation. Our analysis provides a high-confidence group of U2/U12-like non-canonical splice sites, which exhibit distinctive features among the total human splice sites." @default.
• W2117476795 created "2016-06-24" @default.
• W2117476795 creator A5039538767 @default.
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• W2117476795 creator A5087240694 @default.
• W2117476795 creator A5088823319 @default.
• W2117476795 date "2014-08-14" @default.
• W2117476795 modified "2023-10-14" @default.
• W2117476795 title "A comprehensive survey of non-canonical splice sites in the human transcriptome" @default.
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• W2117476795 doi "https://doi.org/10.1093/nar/gku744" @default.
• W2117476795 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4176328" @default.
• W2117476795 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25123659" @default.
• W2117476795 hasPublicationYear "2014" @default.
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