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- W2117492046 abstract "Monoexponential and biexponential disappearance of drug was observed both from the simulated gut phase of a three-phase in vitro model for drug absorption and from the lumen of an in situ rat gut. Monoexponential disappearance occurred when accumulation of drug in the membrane phase was low or absent, whereas biexponential disappearance occurred when membrane accumulation was appreciable. In all cases, overall transfer of drug to blood was essentially irreversible. Kinetic analysis of biexponential lumen phase data, in terms of a two-compartment open model, was accomplished by applying the technique of “feathering.” An analog computer was programmed with the calculated rate constants and the computer generated curves were compared with experimental absorption data from the three phases of the in vitro model. Good agreement between the computer curves and the experimental data confirmed the validity of the computational technique and the accuracy of the individual rate constants. An analog computer was also used to simulate the fraction of the dose of drug in the membrane for the in situ experiments since the membrane was not available for analysis." @default.
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- W2117492046 date "1970-01-01" @default.
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- W2117492046 title "Drug Absorption III: Effect of Membrane Storage on the Kinetics of Drug Absorption" @default.
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- W2117492046 doi "https://doi.org/10.1002/jps.2600590112" @default.
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