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• W2117493067 abstract "Este estudio analiza la biocompatibilidad de nuevos biomateriales a base de hidrogeles metacrílicos como el poli-[metacrilato de 2-etil-(2-pirrolidona)] (PEPM) y la poli-[metacrilato de 2-etil-(2-pirrolidina)], en comparación con referentes comerciales tales como la poli-(vinil pirrolidona) (PVP) y la poli-(N-N´-dimetilacrilamida) (PDMA). Se utilizaron propiedades bioquímicas, mediante los ensayos de MTT y Alamar Blue, para conocer el efecto de citotoxicidad y proliferación en cultivo de fibroblastos (células VERO), sobre los biomateriales metacrílicos. Adicionalmente, por microscopía óptica y electrónica fueron analizados el grado de adhesión, morfología, muerte celular, proliferación, contracción celular, etc. Además se estudiaron las relaciones entre citotoxicidad y estructura química. En el MTT y en el análisis óptico se obtuvo baja citotoxicidad para PEPM y PVP, media en PEPyM y alta en PDMA. En el Alamar Blue y SEM se produjo una media proliferación-adhesión en PEPM y PEPyM, alta en PVP y muerte celular en PDMA. Sus apropiadas características físico-químicas y su aceptable grado de biocompatibilidad les hacen buenos candidatos en aplicaciones tales como lentes de contacto, sistemas de liberación de fármacos e ingeniería de tejidos. This study analyzed biocompatibility of new biomaterials based on the methacrylic hydrogels derived poly-[2-ethyl-(2-pyrrolidone) methacrylate] (PEPM) and poly-[2-ethyl-(2-pyrrolidine) methacrylate] (PEPyM), in comparison with references such as commercial poly-(vinyl pyrrolidone) (PVP) and poly-(N, N-dimethylacrylamide) (PDMA). The biochemical properties were used to know citotoxicity and proliferation effect over fibroblast culture (VERO cells) in contact with the methacrylic biomaterials, using MTT and Alamar Blue assays. Additionally, were analyzed adhesion grade, morphology, death cell presence, proliferation, cell contraction, etc, by optical and scanning electronic microscopy (SEM). The relationships between their chemical structures and cytotoxicity were studied. In MTT and optical analysis, low cytotoxicity was found for PEPM and PVP, medium in the case of PEPyM, and high for PDMA. In Alamar Blue and SEM, were produced a medium proliferation and adhesion rate for PEPM and PEPyM, high in PVP, and cellular death for PDMA. Their appropriates physico-chemical characteristics and approval biocompatibility grade make them good candidates in applications such as contact lenses, drug release systems and tissue engineering." @default.
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• W2117493067 date "2007-01-01" @default.
• W2117493067 modified "2023-09-27" @default.
• W2117493067 title "Estudio de la biocompatibilidad in vitro de polimeros metacrílicos derivados de pirrolidona-ina" @default.
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• W2117493067 doi "https://doi.org/10.5821/sibb.v15i1.1762" @default.
• W2117493067 hasPublicationYear "2007" @default.
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