FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117500864> ?p ?o ?g. }

• W2117500864 endingPage "2672" @default.
• W2117500864 startingPage "2663" @default.
• W2117500864 abstract "We synthesized nanoparticles (NPs) of the blend of two-component copolymers for targeted chemotherapy with paclitaxel used as model drug. One component is poly(lactide)-D-alpha-tocopheryl polyethylene glycol succinate (PLA-TPGS), which is of desired hydrophobic-lipophilic balance, and another is TPGS-COOH, which facilitates the folate conjugation for targeting. The nanoparticles of the two-copolymer blend at various component ratio were prepared by the solvent extraction/evaporation single emulsion method and then decorated by folate, which were characterized by laser light scattering (LLS) for particles' size and size distribution, zeta potential analyzer for surface charge, and X-ray photoelectron spectroscopy (XPS) for surface chemistry. The drug encapsulation efficiency (EE) and in vitro drug release were measured by high performance liquid chromatography (HPLC). The targeting effect was investigated in vitro by cancer cell uptake of coumarin-6-loaded NPs and further confirmed by cytotoxicity of cancer cells treated with the drug formulated in the NPs. We showed that the NP formulation has great advantages vs the pristine drug in achieving better therapeutic effect, which increased 8.68% for MCF-7 breast cancer cells, and that the folate-decoration can significantly promote targeted delivery of the drug into the corresponding cancer cells and thus enhance its therapeutic effect, which increased 24.4% for the NP formulation of 16.7% TPGS-COOH component and 31.1% for the NP formulation of 33.3% TPGS-COOH component after 24h treatment at the same 25 microg/ml paclitaxel concentration. The experiments on C6 glioma cells further confirmed these advantages." @default.
• W2117500864 created "2016-06-24" @default.
• W2117500864 creator A5020390105 @default.
• W2117500864 creator A5090841972 @default.
• W2117500864 date "2008-06-01" @default.
• W2117500864 modified "2023-10-18" @default.
• W2117500864 title "Targeted delivery of paclitaxel using folate-decorated poly(lactide)–vitamin E TPGS nanoparticles" @default.
• W2117500864 cites W1528820340 @default.
• W2117500864 cites W1585705786 @default.
• W2117500864 cites W1762250320 @default.
• W2117500864 cites W1925665128 @default.
• W2117500864 cites W1966960575 @default.
• W2117500864 cites W1967974277 @default.
• W2117500864 cites W1968143647 @default.
• W2117500864 cites W1969020374 @default.
• W2117500864 cites W1972960507 @default.
• W2117500864 cites W1976214499 @default.
• W2117500864 cites W1976356368 @default.
• W2117500864 cites W1978914319 @default.
• W2117500864 cites W1979146480 @default.
• W2117500864 cites W1985426192 @default.
• W2117500864 cites W1988505882 @default.
• W2117500864 cites W1989605629 @default.
• W2117500864 cites W1993666437 @default.
• W2117500864 cites W1995980440 @default.
• W2117500864 cites W2008243045 @default.
• W2117500864 cites W2016750917 @default.
• W2117500864 cites W2021465707 @default.
• W2117500864 cites W2022645876 @default.
• W2117500864 cites W2022885537 @default.
• W2117500864 cites W2023409962 @default.
• W2117500864 cites W2023636496 @default.
• W2117500864 cites W2030855909 @default.
• W2117500864 cites W2033699650 @default.
• W2117500864 cites W2037653676 @default.
• W2117500864 cites W2039123138 @default.
• W2117500864 cites W2042493999 @default.
• W2117500864 cites W2046191257 @default.
• W2117500864 cites W2046528901 @default.
• W2117500864 cites W2046851174 @default.
• W2117500864 cites W2055483349 @default.
• W2117500864 cites W2079184456 @default.
• W2117500864 cites W2080879368 @default.
• W2117500864 cites W2081914868 @default.
• W2117500864 cites W2085363990 @default.
• W2117500864 cites W2087597184 @default.
• W2117500864 cites W2088003991 @default.
• W2117500864 cites W2089319551 @default.
• W2117500864 cites W2093495159 @default.
• W2117500864 cites W2097535374 @default.
• W2117500864 cites W2112719371 @default.
• W2117500864 cites W2123624166 @default.
• W2117500864 cites W2131041162 @default.
• W2117500864 cites W66407225 @default.
• W2117500864 doi "https://doi.org/10.1016/j.biomaterials.2008.02.020" @default.
• W2117500864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18396333" @default.
• W2117500864 hasPublicationYear "2008" @default.
• W2117500864 type Work @default.
• W2117500864 sameAs 2117500864 @default.
• W2117500864 citedByCount "175" @default.
• W2117500864 countsByYear W21175008642012 @default.
• W2117500864 countsByYear W21175008642013 @default.
• W2117500864 countsByYear W21175008642014 @default.
• W2117500864 countsByYear W21175008642015 @default.
• W2117500864 countsByYear W21175008642016 @default.
• W2117500864 countsByYear W21175008642017 @default.
• W2117500864 countsByYear W21175008642018 @default.
• W2117500864 countsByYear W21175008642019 @default.
• W2117500864 countsByYear W21175008642020 @default.
• W2117500864 countsByYear W21175008642021 @default.
• W2117500864 countsByYear W21175008642022 @default.
• W2117500864 countsByYear W21175008642023 @default.
• W2117500864 crossrefType "journal-article" @default.
• W2117500864 hasAuthorship W2117500864A5020390105 @default.
• W2117500864 hasAuthorship W2117500864A5090841972 @default.
• W2117500864 hasConcept C115537861 @default.
• W2117500864 hasConcept C121608353 @default.
• W2117500864 hasConcept C126322002 @default.
• W2117500864 hasConcept C13245373 @default.
• W2117500864 hasConcept C13965031 @default.
• W2117500864 hasConcept C147789679 @default.
• W2117500864 hasConcept C155672457 @default.
• W2117500864 hasConcept C171250308 @default.
• W2117500864 hasConcept C178790620 @default.
• W2117500864 hasConcept C185592680 @default.
• W2117500864 hasConcept C192562407 @default.
• W2117500864 hasConcept C2776964284 @default.
• W2117500864 hasConcept C2777292972 @default.
• W2117500864 hasConcept C2779820397 @default.
• W2117500864 hasConcept C71924100 @default.
• W2117500864 hasConcept C86181022 @default.
• W2117500864 hasConceptScore W2117500864C115537861 @default.
• W2117500864 hasConceptScore W2117500864C121608353 @default.
• W2117500864 hasConceptScore W2117500864C126322002 @default.
• W2117500864 hasConceptScore W2117500864C13245373 @default.
• W2117500864 hasConceptScore W2117500864C13965031 @default.
• W2117500864 hasConceptScore W2117500864C147789679 @default.
• W2117500864 hasConceptScore W2117500864C155672457 @default.

• next