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- W2117509905 abstract "Gastrodia elata (Tianma) is a traditional Chinese medicine often used for the treatment of headache, convulsions, hypertension, and cardiovascular diseases. The vasodilatory actions of Tianma led us to investigate its specific effects on memory and learning as well as on Alzheimer's disease (AD)-related signaling. We conducted a radial arm water maze analysis and the novel object recognition test to assess the cognitive functions of Tianma-treated mice. Our data show that Tianma enhances cognitive functions in mice. Further investigations revealed that Tianma enhances the α-secretase-mediated proteolytic processing of the amyloid precursor protein (App) that precludes the amyloid-β peptide production and supports the non-amyloidogenic processing of App which is favorable in AD treatment. We hypothesize that Tianma promotes cognitive functions and neuronal survival by inhibiting β-site App-cleaving enzyme 1 activity and promoting the neuroprotective α-secretase activity." @default.
- W2117509905 created "2016-06-24" @default.
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- W2117509905 date "2011-01-01" @default.
- W2117509905 modified "2023-10-18" @default.
- W2117509905 title "<i>Gastrodia elata</i> modulates amyloid precursor protein cleavage and cognitive functions in mice" @default.
- W2117509905 cites W1965161192 @default.
- W2117509905 cites W1968017873 @default.
- W2117509905 cites W1969908940 @default.
- W2117509905 cites W1973132378 @default.
- W2117509905 cites W1976760397 @default.
- W2117509905 cites W1980266116 @default.
- W2117509905 cites W1982738872 @default.
- W2117509905 cites W1983245960 @default.
- W2117509905 cites W1984151889 @default.
- W2117509905 cites W1986604088 @default.
- W2117509905 cites W1987271810 @default.
- W2117509905 cites W1989251920 @default.
- W2117509905 cites W1990058257 @default.
- W2117509905 cites W1990078328 @default.
- W2117509905 cites W1992123323 @default.
- W2117509905 cites W1997074109 @default.
- W2117509905 cites W1998649217 @default.
- W2117509905 cites W1998683194 @default.
- W2117509905 cites W1999070279 @default.
- W2117509905 cites W1999343257 @default.
- W2117509905 cites W1999356704 @default.
- W2117509905 cites W2002550351 @default.
- W2117509905 cites W2004585737 @default.
- W2117509905 cites W2010359081 @default.
- W2117509905 cites W2018284875 @default.
- W2117509905 cites W2019253637 @default.
- W2117509905 cites W2022202335 @default.
- W2117509905 cites W2022896819 @default.
- W2117509905 cites W2028350507 @default.
- W2117509905 cites W2029210833 @default.
- W2117509905 cites W2031502387 @default.
- W2117509905 cites W2031561250 @default.
- W2117509905 cites W2033354781 @default.
- W2117509905 cites W2034622555 @default.
- W2117509905 cites W2046373146 @default.
- W2117509905 cites W2047425893 @default.
- W2117509905 cites W2059597433 @default.
- W2117509905 cites W2069608871 @default.
- W2117509905 cites W2080274663 @default.
- W2117509905 cites W2081460149 @default.
- W2117509905 cites W2081843733 @default.
- W2117509905 cites W2082785727 @default.
- W2117509905 cites W2082856972 @default.
- W2117509905 cites W2086557280 @default.
- W2117509905 cites W2087996855 @default.
- W2117509905 cites W2090557159 @default.
- W2117509905 cites W2090818750 @default.
- W2117509905 cites W2092987051 @default.
- W2117509905 cites W2104724669 @default.
- W2117509905 cites W2106459572 @default.
- W2117509905 cites W2108398795 @default.
- W2117509905 cites W2113128264 @default.
- W2117509905 cites W2115309909 @default.
- W2117509905 cites W2119396369 @default.
- W2117509905 cites W2121926098 @default.
- W2117509905 cites W2124135429 @default.
- W2117509905 cites W2127292595 @default.
- W2117509905 cites W2127596545 @default.
- W2117509905 cites W2140736458 @default.
- W2117509905 cites W2145165133 @default.
- W2117509905 cites W2150427335 @default.
- W2117509905 cites W2155783312 @default.
- W2117509905 cites W4214883684 @default.
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- W2117509905 doi "https://doi.org/10.5582/bst.2011.v5.3.129" @default.
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