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- W2117524596 abstract "Background. It has been suggested that monocyte‐related inflammatory mediators play a role in atherosclerosis. Haemodialysis induces phenotypic changes in adhesion molecule expression on monocytes. Soluble vascular cell adhesion molecule‐1 (sVCAM‐1), an adhesion molecule involved in monocyte recruitment, has been proposed to correlate with the extent of atherosclerosis in humans. Monocyte chemotactic protein‐1 (MCP‐1) functions as a monocyte‐specific chemoattractant. Methods. We studied monocyte count, CD11b/CD18 expression on monocytes, MCP‐1, and sVCAM‐1 in nine patients on either cuprophane or polysulphone haemodialysis (n=18 treatments) at times 0 (before haemodialysis), 3 h (end of haemodialysis), 4, 6, 8 and 24 h after start of treatment, as well as in 18 healthy subjects. Results. Monocyte CD11b/CD18 expression increased with both membranes (P<0.001) during and after dialysis compared to before treatment. The concentrations of sVCAM‐1 and MCP‐1 were higher in patients compared to those in controls both before, during and after haemodialysis (P<0.001 at all time points). There were correlations between the expression of CD11b/CD18 on monocytes and the interdialytic concentrations of sVCAM‐1 (r=0.76, P<0.001) and MCP‐1 (r=0.54, P<0.05) and between MCP‐1 and sVCAM‐1 before and after haemodialysis (P<0.05). Conclusion. Patients on haemodialysis have an increased systemic chemotactic activity for monocytes, unphysiological phenotypic alterations in CD11b/ CD18 expression during and after dialysis, and increased sVCAM‐1 and MCP‐1 concentrations. Prospective studies are needed to establish the role of these abnormalities in the pathogenesis of atherosclerosis in haemodialysis patients." @default.
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- W2117524596 date "2000-09-01" @default.
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- W2117524596 title "Three monocyte‐related determinants of atherosclerosis in haemodialysis" @default.
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- W2117524596 doi "https://doi.org/10.1093/ndt/15.9.1414" @default.
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