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• W2117532213 abstract "Triggering receptor expressed on myeloid cells (TREM)-1 is an orphan receptor implicated in innate immune activation. Inhibition of TREM-1 reduces sepsis in mouse models, suggesting a role for it in immune responses triggered by bacteria. However, the absence of an identified ligand has hampered a full understanding of TREM-1 function. We identified complexes between peptidoglycan recognition protein 1 (PGLYRP1) and bacterially derived peptidoglycan that constitute a potent ligand capable of binding TREM-1 and inducing known TREM-1 functions. Interestingly, multimerization of PGLYRP1 bypassed the need for peptidoglycan in TREM-1 activation, demonstrating that the PGLYRP1/TREM-1 axis can be activated in the absence of bacterial products. The role for PGLYRP1 as a TREM-1 activator provides a new mechanism by which bacteria can trigger myeloid cells, linking two known, but previously unrelated, pathways in innate immunity." @default.
• W2117532213 created "2016-06-24" @default.
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• W2117532213 date "2015-01-16" @default.
• W2117532213 modified "2023-10-10" @default.
• W2117532213 title "Cutting Edge: Identification of Neutrophil PGLYRP1 as a Ligand for TREM-1" @default.
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• W2117532213 doi "https://doi.org/10.4049/jimmunol.1402303" @default.
• W2117532213 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4319313" @default.
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