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• W2117532336 endingPage "C1217" @default.
• W2117532336 startingPage "C1207" @default.
• W2117532336 abstract "As increase in collagen deposition is no longer taken as simply a consequence but, rather, an inducer of disease progression; therefore, the understanding of collagen signal transduction is fundamentally important. Cells contain at least two types of collagen receptors: integrins and discoidin domain receptors (DDRs). The integrin heterodimers α 1 β 1 , α 2 β 1 , α 10 β 1 , and α 11 β 1 are recognized as the non-tyrosine kinase collagen receptors. DDR1 and 2, the tyrosine kinase receptors of collagen, are specifically expressed in epithelium and mesenchyme, respectively. While integrin β 1 and DDR1 are both required for cell adhesion on collagen, their roles in epithelial cell differentiation during development and disease progression seem to counteract each other, with integrin β 1 favoring epithelium mesenchyme transition (EMT) and DDR1 inducing epithelial cell differentiation. The in vitro evidence shows that the integrin β 1 and DDR1 exert opposing actions in regulation of membrane stability of E-cadherin, which itself is a critical regulator of epithelial cell differentiation. Here, we review the functional roles of integrin β 1 and DDR1 in regulation of epithelial cell differentiation during development and disease progression, and explore the underlining mechanisms regarding to the regulation of membrane stability of E-cadherin." @default.
• W2117532336 created "2016-06-24" @default.
• W2117532336 creator A5058511539 @default.
• W2117532336 creator A5071217303 @default.
• W2117532336 creator A5078131390 @default.
• W2117532336 date "2012-12-15" @default.
• W2117532336 modified "2023-10-17" @default.
• W2117532336 title "A tale of two collagen receptors, integrin β₁and discoidin domain receptor 1, in epithelial cell differentiation" @default.
• W2117532336 cites W1557028690 @default.
• W2117532336 cites W1937853139 @default.
• W2117532336 cites W1940021039 @default.
• W2117532336 cites W1964081206 @default.
• W2117532336 cites W1970139159 @default.
• W2117532336 cites W1971239528 @default.
• W2117532336 cites W1972747383 @default.
• W2117532336 cites W1973312314 @default.
• W2117532336 cites W1974150901 @default.
• W2117532336 cites W1978692736 @default.
• W2117532336 cites W1982244057 @default.
• W2117532336 cites W1984024996 @default.
• W2117532336 cites W1993864184 @default.
• W2117532336 cites W1994247511 @default.
• W2117532336 cites W1997091783 @default.
• W2117532336 cites W1998112044 @default.
• W2117532336 cites W2001296918 @default.
• W2117532336 cites W2002778380 @default.
• W2117532336 cites W2005214999 @default.
• W2117532336 cites W2008273587 @default.
• W2117532336 cites W2008324315 @default.
• W2117532336 cites W2026918197 @default.
• W2117532336 cites W2028395883 @default.
• W2117532336 cites W2038468856 @default.
• W2117532336 cites W2046031332 @default.
• W2117532336 cites W2046679772 @default.
• W2117532336 cites W2047423042 @default.
• W2117532336 cites W2049177531 @default.
• W2117532336 cites W2055721324 @default.
• W2117532336 cites W2058961362 @default.
• W2117532336 cites W2060126259 @default.
• W2117532336 cites W2061047163 @default.
• W2117532336 cites W2061254715 @default.
• W2117532336 cites W2070783258 @default.
• W2117532336 cites W2073351994 @default.
• W2117532336 cites W2080391612 @default.
• W2117532336 cites W2082994012 @default.
• W2117532336 cites W2086296240 @default.
• W2117532336 cites W2086336177 @default.
• W2117532336 cites W2088904620 @default.
• W2117532336 cites W2091659591 @default.
• W2117532336 cites W2094803625 @default.
• W2117532336 cites W2098410928 @default.
• W2117532336 cites W2099685361 @default.
• W2117532336 cites W2100303404 @default.
• W2117532336 cites W2105495610 @default.
• W2117532336 cites W2106887481 @default.
• W2117532336 cites W2108119086 @default.
• W2117532336 cites W2110689814 @default.
• W2117532336 cites W2111183194 @default.
• W2117532336 cites W2114211654 @default.
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• W2117532336 cites W2123573124 @default.
• W2117532336 cites W2127803449 @default.
• W2117532336 cites W2133120721 @default.
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• W2117532336 cites W2140107075 @default.
• W2117532336 cites W2140640398 @default.
• W2117532336 cites W2142127733 @default.
• W2117532336 cites W2145280913 @default.
• W2117532336 cites W2146078095 @default.
• W2117532336 cites W2146322233 @default.
• W2117532336 cites W2147186803 @default.
• W2117532336 cites W2147451740 @default.
• W2117532336 cites W2147887967 @default.
• W2117532336 cites W2148501741 @default.
• W2117532336 cites W2149238701 @default.
• W2117532336 cites W2150647358 @default.
• W2117532336 cites W2153595347 @default.
• W2117532336 cites W2154086186 @default.
• W2117532336 cites W2155890759 @default.
• W2117532336 cites W2156581417 @default.
• W2117532336 cites W2158460250 @default.
• W2117532336 cites W2159216068 @default.
• W2117532336 cites W2162045495 @default.
• W2117532336 cites W2164490839 @default.
• W2117532336 cites W2168181903 @default.
• W2117532336 cites W2168545077 @default.
• W2117532336 cites W2325413783 @default.
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• W2117532336 doi "https://doi.org/10.1152/ajpcell.00253.2012" @default.
• W2117532336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23015544" @default.
• W2117532336 hasPublicationYear "2012" @default.
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