FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117543837> ?p ?o ?g. }

• W2117543837 abstract "Urokinase (UK) 2 200 U/kg·h for 12 hours infusion(UK-12 h)is an ACCP recommended regimen in treating acute pulmonary embolism (PE). It is unclear whether this dose and time can be reduced further. We compared the efficacy and safety of 20, 000 U/kg for 2 hours (UK-2 h) with the UK-12 h regime in selected PE patients. A randomized trial involving 129 patients was conducted. Patients with acute PE were randomly assigned to receive either UK-12 h (n = 70), or UK-2 h (n = 59). The efficacy was determined by the improvement of right heart dysfunction and perfusion defect at 24 h and 14 d post UK treatment. The bleeding incidence, death rate and PE recurrence were also evaluated. Similarly significant improvements in right heart dysfunction and lung perfusion defects were observed in both groups. Overall bleeding incidents were low in both groups. Major bleeding directly associated with UK infusion occurred in one patient in the UK-2 h group and one in the UK-12 h group. Mortality rates were low, with one reported fatal recurrent in the UK-12 h group and none in the UK-2 h group. When the rate of bleeding, death and PE recurrence were compared separately in the hemodynamic instability and the massive anatomic obstruction subgroups, no significant difference was found. The UK-2 h regimen exhibits similar efficacy and safety as the UK-12 h regimen for acute PE. Clinical trial registered with http://clinicaltrials.gov/ct2/show/NCT00799968 (Identifier: NCT 00799968)" @default.
• W2117543837 created "2016-06-24" @default.
• W2117543837 creator A5013038112 @default.
• W2117543837 creator A5015718852 @default.
• W2117543837 creator A5022267524 @default.
• W2117543837 creator A5022675390 @default.
• W2117543837 creator A5023398611 @default.
• W2117543837 creator A5028740838 @default.
• W2117543837 creator A5040267796 @default.
• W2117543837 creator A5045796794 @default.
• W2117543837 creator A5056355876 @default.
• W2117543837 creator A5063917024 @default.
• W2117543837 creator A5074516183 @default.
• W2117543837 creator A5085604392 @default.
• W2117543837 date "2009-12-01" @default.
• W2117543837 modified "2023-09-26" @default.
• W2117543837 title "Efficacy and safety of 2-hour urokinase regime in acute pulmonary embolism: a randomized controlled trial" @default.
• W2117543837 cites W1490174486 @default.
• W2117543837 cites W1510542347 @default.
• W2117543837 cites W171739323 @default.
• W2117543837 cites W1965505881 @default.
• W2117543837 cites W1980057645 @default.
• W2117543837 cites W1986023474 @default.
• W2117543837 cites W1987892547 @default.
• W2117543837 cites W1993765899 @default.
• W2117543837 cites W2022993510 @default.
• W2117543837 cites W2042750686 @default.
• W2117543837 cites W2044055043 @default.
• W2117543837 cites W2053156671 @default.
• W2117543837 cites W2058162669 @default.
• W2117543837 cites W2079371665 @default.
• W2117543837 cites W2085984247 @default.
• W2117543837 cites W2086778623 @default.
• W2117543837 cites W2097055290 @default.
• W2117543837 cites W2125364389 @default.
• W2117543837 cites W2156320702 @default.
• W2117543837 cites W2160443953 @default.
• W2117543837 cites W2170571545 @default.
• W2117543837 cites W2408177944 @default.
• W2117543837 cites W4251433429 @default.
• W2117543837 cites W4252126265 @default.
• W2117543837 doi "https://doi.org/10.1186/1465-9921-10-128" @default.
• W2117543837 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2806365" @default.
• W2117543837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20040086" @default.
• W2117543837 hasPublicationYear "2009" @default.
• W2117543837 type Work @default.
• W2117543837 sameAs 2117543837 @default.
• W2117543837 citedByCount "21" @default.
• W2117543837 countsByYear W21175438372012 @default.
• W2117543837 countsByYear W21175438372013 @default.
• W2117543837 countsByYear W21175438372014 @default.
• W2117543837 countsByYear W21175438372015 @default.
• W2117543837 countsByYear W21175438372017 @default.
• W2117543837 countsByYear W21175438372018 @default.
• W2117543837 countsByYear W21175438372021 @default.
• W2117543837 countsByYear W21175438372022 @default.
• W2117543837 crossrefType "journal-article" @default.
• W2117543837 hasAuthorship W2117543837A5013038112 @default.
• W2117543837 hasAuthorship W2117543837A5015718852 @default.
• W2117543837 hasAuthorship W2117543837A5022267524 @default.
• W2117543837 hasAuthorship W2117543837A5022675390 @default.
• W2117543837 hasAuthorship W2117543837A5023398611 @default.
• W2117543837 hasAuthorship W2117543837A5028740838 @default.
• W2117543837 hasAuthorship W2117543837A5040267796 @default.
• W2117543837 hasAuthorship W2117543837A5045796794 @default.
• W2117543837 hasAuthorship W2117543837A5056355876 @default.
• W2117543837 hasAuthorship W2117543837A5063917024 @default.
• W2117543837 hasAuthorship W2117543837A5074516183 @default.
• W2117543837 hasAuthorship W2117543837A5085604392 @default.
• W2117543837 hasBestOaLocation W21175438371 @default.
• W2117543837 hasConcept C126322002 @default.
• W2117543837 hasConcept C141071460 @default.
• W2117543837 hasConcept C168563851 @default.
• W2117543837 hasConcept C179755657 @default.
• W2117543837 hasConcept C2776265017 @default.
• W2117543837 hasConcept C2776892390 @default.
• W2117543837 hasConcept C2781413609 @default.
• W2117543837 hasConcept C71924100 @default.
• W2117543837 hasConceptScore W2117543837C126322002 @default.
• W2117543837 hasConceptScore W2117543837C141071460 @default.
• W2117543837 hasConceptScore W2117543837C168563851 @default.
• W2117543837 hasConceptScore W2117543837C179755657 @default.
• W2117543837 hasConceptScore W2117543837C2776265017 @default.
• W2117543837 hasConceptScore W2117543837C2776892390 @default.
• W2117543837 hasConceptScore W2117543837C2781413609 @default.
• W2117543837 hasConceptScore W2117543837C71924100 @default.
• W2117543837 hasIssue "1" @default.
• W2117543837 hasLocation W21175438371 @default.
• W2117543837 hasLocation W21175438372 @default.
• W2117543837 hasLocation W21175438373 @default.
• W2117543837 hasLocation W21175438374 @default.
• W2117543837 hasOpenAccess W2117543837 @default.
• W2117543837 hasPrimaryLocation W21175438371 @default.
• W2117543837 hasRelatedWork W120910089 @default.
• W2117543837 hasRelatedWork W2026546135 @default.
• W2117543837 hasRelatedWork W2375104778 @default.
• W2117543837 hasRelatedWork W2379497856 @default.
• W2117543837 hasRelatedWork W2388006442 @default.
• W2117543837 hasRelatedWork W2401024977 @default.
• W2117543837 hasRelatedWork W2475264243 @default.

• next