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- W2117557467 abstract "Abstract The wound-healing process induced by chronic hepatitis C virus (HCV) infection triggers liver damage characterized by fibrosis development and finally cirrhosis. Liver Transplantation (LT) is the optimal surgical treatment for HCV-cirrhotic patients at end-stage liver disease. However, acute cellular rejection (ACR) and HCV recurrence disease represent two devastating complications post-LT. The accurate differential diagnosis between both conditions is critical for treatment choice, and similar histological features represent a challenge for pathologists. Moreover, the HCV recurrence disease severity is highly variable post-LT. HCV recurrence disease progression is characterized by an accelerated fibrogenesis process, and almost 30% of those patients develop cirrhosis at 5-years of follow-up. Whole-genome gene expression (WGE) analyses through well-defined oligonucleotide microarray platforms represent a powerful tool for the molecular characterization of biological process. In the present manuscript, the utility of microarray technology is applied for the ACR and HCV-recurrence biological characterization in post-LT liver biopsy samples. Moreover, WGE analysis was performed to identify predictive biomarkers of HCV recurrence severity in formalin-fixed paraffin-embedded liver biopsies prospectively collected." @default.
- W2117557467 created "2016-06-24" @default.
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- W2117557467 date "2012-06-06" @default.
- W2117557467 modified "2023-09-24" @default.
- W2117557467 title "Biomarkers of disease differentiation: HCV recurrence versus acute cellular rejection" @default.
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- W2117557467 doi "https://doi.org/10.1186/1755-1536-5-s1-s11" @default.
- W2117557467 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3368799" @default.
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