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- W2117575003 endingPage "58" @default.
- W2117575003 startingPage "43" @default.
- W2117575003 abstract "Schizophrenia is a complex mental health disorder with positive, negative and cognitive symptom domains. Approximately one third of patients are resistant to currently available medication. New therapeutic targets and a better understanding of the basic biological processes that drive pathogenesis are needed in order to develop therapies that will improve quality of life for these patients. Several drugs that act on neurotransmitter systems in the brain have been suggested to model aspects of schizophrenia in animals and in man. In this paper, we selectively review findings from dopaminergic, glutamatergic, serotonergic, cannabinoid, GABA, cholinergic and kappa opioid pharmacological drug models to evaluate their similarity to schizophrenia. Understanding the interactions between these different neurotransmitter systems and their relationship with symptoms will be an important step towards building a coherent hypothesis for the pathogenesis of schizophrenia." @default.
- W2117575003 created "2016-06-24" @default.
- W2117575003 creator A5038609897 @default.
- W2117575003 creator A5053590250 @default.
- W2117575003 creator A5059076724 @default.
- W2117575003 date "2014-11-09" @default.
- W2117575003 modified "2023-09-27" @default.
- W2117575003 title "Drug models of schizophrenia" @default.
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