FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117582013> ?p ?o ?g. }

• W2117582013 endingPage "858" @default.
• W2117582013 startingPage "849" @default.
• W2117582013 abstract "We have taken advantage of some unique properties of H-2Ld to investigate the determinant density requirements for cytotoxic T lymphocyte (CTL) priming versus effector function and to correlate the determinant density requirements with CD8 dependency. In a previous study (Lie, W.-R., N. B. Myers, J. Gorka, R. J. Rubocki, J. M. Connolly, and T. H. Hansen. 1990. Nature [Lond.]. 344:439), we demonstrated that culturing normal cells with peptides known to be restricted by H-2Ld led to a two- to fourfold increase in surface Ld expression. In the present study, we demonstrate the generation of Ld-restricted, peptide-specific in vitro primary CTL by culturing spleen cells with murine cytomegalovirus or tum- peptide at concentrations previously shown to result in maximum induction of Ld expression. Target cells can be sensitized for recognition by these CTL with lower dose of peptide than are required for the primary sensitization. This demonstrates differences in the determinant density requirements for priming versus effector function. The in vitro primary CTL generated with peptide can weakly lyse target cells that express the determinant endogenously, and CTL lines and clones capable of strong lysis of endogenous expressors are easily obtained. In both cases, target cells treated with exogenous peptide are lysed better than target cells expressing antigen endogenously. This suggested that there are differences in the determinant density of peptide-fed versus endogenous targets. This interpretation was substantiated when it was observed that the level of lysis of target cells expressing endogenous determinants correlated inversely with the amount of peptide required to sensitize targets for recognition by various tum- -specific CTL clones. Furthermore, simultaneous titration of both the peptide used to treat target cells and the antibody to CD8 revealed that the various CTL clones analyzed displayed widely disparate CD8 dependencies. In each case, the CD8 dependency correlated inversely with the determinant density requirement. Therefore, CD8 dependency of CTL is relative, but shows an absolute and quantitative correlation with their dependency on determinant density. These findings suggest that under physiologic conditions, where only low determinant densities are likely to be encountered, all CTL clones will show at least partial CD8 dependency." @default.
• W2117582013 created "2016-06-24" @default.
• W2117582013 creator A5004768728 @default.
• W2117582013 creator A5019599195 @default.
• W2117582013 creator A5028584310 @default.
• W2117582013 creator A5072532618 @default.
• W2117582013 creator A5082140305 @default.
• W2117582013 date "1991-04-01" @default.
• W2117582013 modified "2023-09-23" @default.
• W2117582013 title "Correlation between CD8 dependency and determinant density using peptide-induced, Ld-restricted cytotoxic T lymphocytes." @default.
• W2117582013 cites W1497278722 @default.
• W2117582013 cites W1499318663 @default.
• W2117582013 cites W1527191816 @default.
• W2117582013 cites W1533542807 @default.
• W2117582013 cites W1597051205 @default.
• W2117582013 cites W1628607703 @default.
• W2117582013 cites W1745995307 @default.
• W2117582013 cites W1976557235 @default.
• W2117582013 cites W1981366552 @default.
• W2117582013 cites W1984512389 @default.
• W2117582013 cites W2008564146 @default.
• W2117582013 cites W2009228522 @default.
• W2117582013 cites W2026923875 @default.
• W2117582013 cites W2029993034 @default.
• W2117582013 cites W2033370352 @default.
• W2117582013 cites W2048310562 @default.
• W2117582013 cites W2060820609 @default.
• W2117582013 cites W2064813062 @default.
• W2117582013 cites W2072903392 @default.
• W2117582013 cites W2078547056 @default.
• W2117582013 cites W2104453235 @default.
• W2117582013 cites W2108777421 @default.
• W2117582013 cites W2114207215 @default.
• W2117582013 cites W2120479947 @default.
• W2117582013 cites W2138820324 @default.
• W2117582013 cites W2145635105 @default.
• W2117582013 cites W2170402078 @default.
• W2117582013 cites W2180597555 @default.
• W2117582013 cites W2413580108 @default.
• W2117582013 doi "https://doi.org/10.1084/jem.173.4.849" @default.
• W2117582013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2190800" @default.
• W2117582013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1901079" @default.
• W2117582013 hasPublicationYear "1991" @default.
• W2117582013 type Work @default.
• W2117582013 sameAs 2117582013 @default.
• W2117582013 citedByCount "117" @default.
• W2117582013 countsByYear W21175820132012 @default.
• W2117582013 countsByYear W21175820132013 @default.
• W2117582013 countsByYear W21175820132015 @default.
• W2117582013 countsByYear W21175820132016 @default.
• W2117582013 countsByYear W21175820132017 @default.
• W2117582013 countsByYear W21175820132020 @default.
• W2117582013 crossrefType "journal-article" @default.
• W2117582013 hasAuthorship W2117582013A5004768728 @default.
• W2117582013 hasAuthorship W2117582013A5019599195 @default.
• W2117582013 hasAuthorship W2117582013A5028584310 @default.
• W2117582013 hasAuthorship W2117582013A5072532618 @default.
• W2117582013 hasAuthorship W2117582013A5082140305 @default.
• W2117582013 hasBestOaLocation W21175820131 @default.
• W2117582013 hasConcept C100701293 @default.
• W2117582013 hasConcept C147483822 @default.
• W2117582013 hasConcept C147969180 @default.
• W2117582013 hasConcept C153911025 @default.
• W2117582013 hasConcept C154317977 @default.
• W2117582013 hasConcept C16613235 @default.
• W2117582013 hasConcept C167672396 @default.
• W2117582013 hasConcept C195616568 @default.
• W2117582013 hasConcept C202751555 @default.
• W2117582013 hasConcept C203014093 @default.
• W2117582013 hasConcept C2779281246 @default.
• W2117582013 hasConcept C51785407 @default.
• W2117582013 hasConcept C55493867 @default.
• W2117582013 hasConcept C59822182 @default.
• W2117582013 hasConcept C81444415 @default.
• W2117582013 hasConcept C86803240 @default.
• W2117582013 hasConcept C95444343 @default.
• W2117582013 hasConceptScore W2117582013C100701293 @default.
• W2117582013 hasConceptScore W2117582013C147483822 @default.
• W2117582013 hasConceptScore W2117582013C147969180 @default.
• W2117582013 hasConceptScore W2117582013C153911025 @default.
• W2117582013 hasConceptScore W2117582013C154317977 @default.
• W2117582013 hasConceptScore W2117582013C16613235 @default.
• W2117582013 hasConceptScore W2117582013C167672396 @default.
• W2117582013 hasConceptScore W2117582013C195616568 @default.
• W2117582013 hasConceptScore W2117582013C202751555 @default.
• W2117582013 hasConceptScore W2117582013C203014093 @default.
• W2117582013 hasConceptScore W2117582013C2779281246 @default.
• W2117582013 hasConceptScore W2117582013C51785407 @default.
• W2117582013 hasConceptScore W2117582013C55493867 @default.
• W2117582013 hasConceptScore W2117582013C59822182 @default.
• W2117582013 hasConceptScore W2117582013C81444415 @default.
• W2117582013 hasConceptScore W2117582013C86803240 @default.
• W2117582013 hasConceptScore W2117582013C95444343 @default.
• W2117582013 hasIssue "4" @default.
• W2117582013 hasLocation W21175820131 @default.
• W2117582013 hasLocation W21175820132 @default.
• W2117582013 hasLocation W21175820133 @default.
• W2117582013 hasLocation W21175820134 @default.

• next