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• W2117604328 startingPage "4283" @default.
• W2117604328 abstract "Abstract Matrix metalloproteinase-8 (MMP-8) is a potent interstitial collagenase thought to be expressed mainly by polymorphonuclear neutrophils. To determine whether MMP-8 regulates lung inflammatory or fibrotic responses to bleomycin, we delivered bleomycin by the intratracheal route to wild-type (WT) versus Mmp-8−/− mice and quantified MMP-8 expression, and inflammation and fibrosis in the lung samples. Mmp-8 steady state mRNA and protein levels increase in whole lung and bronchoalveolar lavage samples when WT mice are treated with bleomycin. Activated murine lung fibroblasts express Mmp-8 in vitro. MMP-8 expression is increased in leukocytes in the lungs of patients with idiopathic pulmonary fibrosis compared with control lung samples. Compared with bleomycin-treated WT mice, bleomycin-treated Mmp-8−/− mice have greater lung inflammation, but reduced lung fibrosis. Whereas bleomycin-treated Mmp-8−/− and WT mice have similar lung levels of several pro- and antifibrotic mediators (TGF-β, IL-13, JE, and IFN-γ), Mmp-8−/− mice have higher lung levels of IFN-γ–inducible protein-10 (IP-10) and MIP-1α. Genetically deleting either Ip-10 or Mip-1α in Mmp-8−/− mice abrogates their lung inflammatory response to bleomycin, but reconstitutes their lung fibrotic response to bleomycin. Studies of bleomycin-treated Mmp-8 bone marrow chimeric mice show that both leukocytes and lung parenchymal cells are sources of profibrotic MMP-8 during bleomycin-mediated lung fibrosis. Thus, during bleomycin-mediated lung injury, MMP-8 dampens the lung acute inflammatory response, but promotes lung fibrosis by reducing lung levels of IP-10 and MIP-1α. These data indicate therapeutic strategies to reduce lung levels of MMP-8 may limit fibroproliferative responses to injury in the human lung." @default.
• W2117604328 created "2016-06-24" @default.
• W2117604328 creator A5001547875 @default.
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• W2117604328 date "2013-04-15" @default.
• W2117604328 modified "2023-10-06" @default.
• W2117604328 title "Profibrotic Activities for Matrix Metalloproteinase-8 during Bleomycin-Mediated Lung Injury" @default.
• W2117604328 cites W1484628070 @default.
• W2117604328 cites W1486777323 @default.
• W2117604328 cites W1488444587 @default.
• W2117604328 cites W1505978562 @default.
• W2117604328 cites W1521619375 @default.
• W2117604328 cites W1523096910 @default.
• W2117604328 cites W1532091886 @default.
• W2117604328 cites W1542530639 @default.
• W2117604328 cites W1548455476 @default.
• W2117604328 cites W1579523746 @default.
• W2117604328 cites W1667509742 @default.
• W2117604328 cites W1804633340 @default.
• W2117604328 cites W1910308666 @default.
• W2117604328 cites W1934903117 @default.
• W2117604328 cites W1966328299 @default.
• W2117604328 cites W1971768473 @default.
• W2117604328 cites W1973621813 @default.
• W2117604328 cites W1973724657 @default.
• W2117604328 cites W1974005261 @default.
• W2117604328 cites W1984326813 @default.
• W2117604328 cites W1987437052 @default.
• W2117604328 cites W1989999956 @default.
• W2117604328 cites W1990584310 @default.
• W2117604328 cites W1991268098 @default.
• W2117604328 cites W1995409171 @default.
• W2117604328 cites W1997082999 @default.
• W2117604328 cites W1998312828 @default.
• W2117604328 cites W2002825253 @default.
• W2117604328 cites W2006953467 @default.
• W2117604328 cites W2010087085 @default.
• W2117604328 cites W2015047621 @default.
• W2117604328 cites W2015116686 @default.
• W2117604328 cites W2033671240 @default.
• W2117604328 cites W2034287052 @default.
• W2117604328 cites W2034462747 @default.
• W2117604328 cites W2036387557 @default.
• W2117604328 cites W2037268333 @default.
• W2117604328 cites W2042383304 @default.
• W2117604328 cites W2044478331 @default.
• W2117604328 cites W2046362689 @default.
• W2117604328 cites W2051082996 @default.
• W2117604328 cites W2052798492 @default.
• W2117604328 cites W2053063976 @default.
• W2117604328 cites W2054797017 @default.
• W2117604328 cites W2059978214 @default.
• W2117604328 cites W2060294130 @default.
• W2117604328 cites W2064222334 @default.
• W2117604328 cites W2065977597 @default.
• W2117604328 cites W2070595030 @default.
• W2117604328 cites W2078658994 @default.
• W2117604328 cites W2083876822 @default.
• W2117604328 cites W2087356899 @default.
• W2117604328 cites W2087749727 @default.
• W2117604328 cites W2091360431 @default.
• W2117604328 cites W2091929727 @default.
• W2117604328 cites W2098765934 @default.
• W2117604328 cites W2101738319 @default.
• W2117604328 cites W2102473755 @default.
• W2117604328 cites W2107272258 @default.
• W2117604328 cites W2108679807 @default.
• W2117604328 cites W2111920665 @default.
• W2117604328 cites W2116606473 @default.
• W2117604328 cites W2120446140 @default.
• W2117604328 cites W2120532099 @default.
• W2117604328 cites W2122010894 @default.
• W2117604328 cites W2130172749 @default.
• W2117604328 cites W2132290892 @default.
• W2117604328 cites W2134664605 @default.
• W2117604328 cites W2140590112 @default.
• W2117604328 cites W2140626436 @default.
• W2117604328 cites W2141023843 @default.
• W2117604328 cites W2142862368 @default.
• W2117604328 cites W2144310026 @default.
• W2117604328 cites W2145930147 @default.
• W2117604328 cites W2153774908 @default.
• W2117604328 cites W2154619356 @default.
• W2117604328 cites W2160639837 @default.
• W2117604328 cites W2163601934 @default.
• W2117604328 cites W2163702064 @default.
• W2117604328 cites W2164209124 @default.
• W2117604328 cites W2164998164 @default.
• W2117604328 cites W2168760383 @default.
• W2117604328 cites W2170332275 @default.
• W2117604328 cites W2186896904 @default.
• W2117604328 cites W4210447124 @default.
• W2117604328 cites W4294216491 @default.

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