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- W2117613919 abstract "The role of IL-17 and Th17 cells in immunity vs. pathology associated with the human commensal Candida albicans remains controversial. Both positive and negative effects on immune resistance have been attributed to IL-17/Th17 in experimental candidiasis. In this study, we provide evidence that IL-22, which is also produced by Th17 cells, has a critical, first-line defense in candidiasis by controlling the growth of infecting yeasts as well as by contributing to the host's epithelial integrity in the absence of acquired Th1-type immunity. The two pathways are reciprocally regulated, and IL-22 is upregulated under Th1 deficiency conditions and vice versa. Whereas both IL-17A and F are dispensable for antifungal resistance, IL-22 mediates protection in IL-17RA-deficient mice, in which IL-17A contributes to disease susceptibility. Thus, our findings suggest that protective immunity to candidiasis is made up of a staged response involving an early, IL-22-dominated response followed by Th1/Treg reactivity that will prevent fungal dissemination and supply memory." @default.
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- W2117613919 date "2010-07-01" @default.
- W2117613919 modified "2023-10-16" @default.
- W2117613919 title "IL-22 defines a novel immune pathway of antifungal resistance" @default.
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- W2117613919 doi "https://doi.org/10.1038/mi.2010.22" @default.
- W2117613919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20445503" @default.
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