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- W2117613986 abstract "In this study, we determined the protective effect of total flavonoids from Spirodela polyrrhiza (L.) Schleid (STF), which is a kind of traditional Chinese medicine, on human umbilical vein endothelial cells (ECV-304) damage induced by hydrogen peroxide (H2O2). Treated with 1 mmol/L H2O2 for 1 h, the viability of ECV-304 cells markedly decreased. However, pretreatment with 10–50 μg/mL STF resulted in a significant recovery. The survival rate of ECV-304 increased from 21.98% (only treated with 1 mmol/L H2O2) to 64.74% (pretreated with 50 μg/mL STF), which accompanied with the amounts of malondialdenhyde (MDA) decreasing from 1.6883 nmol/L to 0.9628 nmol/L. Furthermore, compared with control group, the 50 μmol/L STF pretreatment enhanced the total antioxidant capacity (T-AOC) by 4.49 times, increased the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) by 85.12%, 158.94% and 94.5%,respectively, and increased the content of nitric oxide (NO) by 116.55%.Taken together, STF protect ECV-304 cells against H2O2 damage by enhancing the antioxidant ability and increasing NO production." @default.
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- W2117613986 date "2007-10-01" @default.
- W2117613986 modified "2023-10-07" @default.
- W2117613986 title "Protective effect of total flavonoids from Spirodela polyrrhiza (L.) Schleid on human umbilical vein endothelial cell damage induced by hydrogen peroxide" @default.
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- W2117613986 doi "https://doi.org/10.1016/j.colsurfb.2007.05.020" @default.
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