FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117621140> ?p ?o ?g. }

• W2117621140 endingPage "C64" @default.
• W2117621140 startingPage "C57" @default.
• W2117621140 abstract "Evidence suggests that 1) ischemia-reperfusion injury is due largely to cytosolic Ca 2+ accumulation resulting from functional coupling of Na + /Ca 2+ exchange (NCE) with stimulated Na + /H + exchange (NHE1) and 2) 17β-estradiol (E2) stimulates release of NO, which inhibits NHE1. Thus we tested the hypothesis that acute E2 limits myocardial Na + and therefore Ca 2+ accumulation, thereby limiting ischemia-reperfusion injury. NMR was used to measure cytosolic pH (pH i ), Na + (Na[Formula: see text]), and calcium concentration ([Ca 2+ ] i ) in Krebs-Henseleit (KH)-perfused hearts from ovariectomized rats (OVX). Left ventricular developed pressure (LVDP) and lactate dehydrogenase (LDH) release were also measured. Control ischemia-reperfusion was 20 min of baseline perfusion, 40 min of global ischemia, and 40 min of reperfusion. The E2 protocol was identical, except that 1 nM E2 was included in the perfusate before ischemia and during reperfusion. E2 significantly limited the changes in pH i , Na[Formula: see text] and [Ca 2+ ] i during ischemia ( P < 0.05). In control OVX vs. OVX+E2, pH i fell from 6.93 ± 0.03 to 5.98 ± 0.04 vs. 6.96 ± 0.04 to 6.68 ± 0.07; Na[Formula: see text] rose from 25 ± 6 to 109 ± 14 meq/kg dry wt vs. 25 ± 1 to 76 ± 3; [Ca 2+ ] i changed from 365 ± 69 to 1,248 ± 180 nM vs. 293 ± 66 to 202 ± 64 nM. E2 also improved recovery of LVDP and diminished release of LDH during reperfusion. Effects of E2 were diminished by 1 μM N ω -nitro-l-arginine methyl ester. Thus the data are consistent with the hypothesis. However, E2 limitation of increases in [Ca 2+ ] i is greater than can be accounted for by the thermodynamic effect of reduced Na[Formula: see text] accumulation on NCE." @default.
• W2117621140 created "2016-06-24" @default.
• W2117621140 creator A5017041251 @default.
• W2117621140 creator A5020880733 @default.
• W2117621140 creator A5056296999 @default.
• W2117621140 creator A5063383331 @default.
• W2117621140 date "2005-01-01" @default.
• W2117621140 modified "2023-09-30" @default.
• W2117621140 title "Acute effects of 17β-estradiol on myocardial pH, Na⁺, and Ca²⁺ and ischemia-reperfusion injury" @default.
• W2117621140 cites W1578911381 @default.
• W2117621140 cites W1803128538 @default.
• W2117621140 cites W1855340107 @default.
• W2117621140 cites W1946715896 @default.
• W2117621140 cites W1972327757 @default.
• W2117621140 cites W1973418332 @default.
• W2117621140 cites W1974130627 @default.
• W2117621140 cites W1985251254 @default.
• W2117621140 cites W1985832800 @default.
• W2117621140 cites W1986231522 @default.
• W2117621140 cites W1989395892 @default.
• W2117621140 cites W1990374532 @default.
• W2117621140 cites W1995011623 @default.
• W2117621140 cites W1995304200 @default.
• W2117621140 cites W1997821840 @default.
• W2117621140 cites W2011864116 @default.
• W2117621140 cites W2029864607 @default.
• W2117621140 cites W2031693554 @default.
• W2117621140 cites W2046514868 @default.
• W2117621140 cites W2047563687 @default.
• W2117621140 cites W2047968184 @default.
• W2117621140 cites W2048867592 @default.
• W2117621140 cites W2053135322 @default.
• W2117621140 cites W2056935824 @default.
• W2117621140 cites W2068499122 @default.
• W2117621140 cites W2077402305 @default.
• W2117621140 cites W2078365057 @default.
• W2117621140 cites W2079550128 @default.
• W2117621140 cites W2087228724 @default.
• W2117621140 cites W2107298480 @default.
• W2117621140 cites W2115993532 @default.
• W2117621140 cites W2126244064 @default.
• W2117621140 cites W2126753136 @default.
• W2117621140 cites W2130909570 @default.
• W2117621140 cites W2140182623 @default.
• W2117621140 cites W2146831679 @default.
• W2117621140 cites W2154005496 @default.
• W2117621140 cites W2159454962 @default.
• W2117621140 cites W2171377757 @default.
• W2117621140 cites W2187968194 @default.
• W2117621140 cites W2188166915 @default.
• W2117621140 cites W2229149116 @default.
• W2117621140 cites W2277645989 @default.
• W2117621140 cites W2280010169 @default.
• W2117621140 cites W2315431723 @default.
• W2117621140 cites W2408389579 @default.
• W2117621140 cites W2419217164 @default.
• W2117621140 doi "https://doi.org/10.1152/ajpcell.00414.2004" @default.
• W2117621140 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15385267" @default.
• W2117621140 hasPublicationYear "2005" @default.
• W2117621140 type Work @default.
• W2117621140 sameAs 2117621140 @default.
• W2117621140 citedByCount "22" @default.
• W2117621140 countsByYear W21176211402012 @default.
• W2117621140 countsByYear W21176211402013 @default.
• W2117621140 countsByYear W21176211402016 @default.
• W2117621140 countsByYear W21176211402017 @default.
• W2117621140 countsByYear W21176211402019 @default.
• W2117621140 countsByYear W21176211402021 @default.
• W2117621140 countsByYear W21176211402022 @default.
• W2117621140 countsByYear W21176211402023 @default.
• W2117621140 crossrefType "journal-article" @default.
• W2117621140 hasAuthorship W2117621140A5017041251 @default.
• W2117621140 hasAuthorship W2117621140A5020880733 @default.
• W2117621140 hasAuthorship W2117621140A5056296999 @default.
• W2117621140 hasAuthorship W2117621140A5063383331 @default.
• W2117621140 hasConcept C126322002 @default.
• W2117621140 hasConcept C134018914 @default.
• W2117621140 hasConcept C146957229 @default.
• W2117621140 hasConcept C181199279 @default.
• W2117621140 hasConcept C185592680 @default.
• W2117621140 hasConcept C2777318727 @default.
• W2117621140 hasConcept C2780114680 @default.
• W2117621140 hasConcept C519063684 @default.
• W2117621140 hasConcept C541997718 @default.
• W2117621140 hasConcept C55493867 @default.
• W2117621140 hasConcept C71924100 @default.
• W2117621140 hasConceptScore W2117621140C126322002 @default.
• W2117621140 hasConceptScore W2117621140C134018914 @default.
• W2117621140 hasConceptScore W2117621140C146957229 @default.
• W2117621140 hasConceptScore W2117621140C181199279 @default.
• W2117621140 hasConceptScore W2117621140C185592680 @default.
• W2117621140 hasConceptScore W2117621140C2777318727 @default.
• W2117621140 hasConceptScore W2117621140C2780114680 @default.
• W2117621140 hasConceptScore W2117621140C519063684 @default.
• W2117621140 hasConceptScore W2117621140C541997718 @default.
• W2117621140 hasConceptScore W2117621140C55493867 @default.
• W2117621140 hasConceptScore W2117621140C71924100 @default.
• W2117621140 hasIssue "1" @default.

• next