FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117621180> ?p ?o ?g. }

• W2117621180 abstract "Human and murine cerebral malaria are associated with elevated levels of cytokines in the brain and adherence of platelets to the microvasculature. Here we demonstrated that the accumulation of platelets in the brain microvasculature can be detected with MRI, using what we believe to be a novel contrast agent, at a time when the pathology is undetectable by conventional MRI. Ligand-induced binding sites (LIBS) on activated platelet glycoprotein IIb/IIIa receptors were detected in the brains of malaria-infected mice 6 days after inoculation with Plasmodium berghei using microparticles of iron oxide (MPIOs) conjugated to a single-chain antibody specific for the LIBS (LIBS-MPIO). No binding of the LIBS-MPIO contrast agent was detected in uninfected animals. A combination of LIBS-MPIO MRI, confocal microscopy, and transmission electron microscopy revealed that the proinflammatory cytokine TNF-alpha, but not IL-1beta or lymphotoxin-alpha (LT-alpha), induced adherence of platelets to cerebrovascular endothelium. Peak platelet adhesion was found 12 h after TNF-alpha injection and was readily detected with LIBS-MPIO contrast-enhanced MRI. Temporal studies revealed that the level of MPIO-induced contrast was proportional to the number of platelets bound. Thus, the LIBS-MPIO contrast agent enabled noninvasive detection of otherwise undetectable cerebral pathology by in vivo MRI before the appearance of clinical disease, highlighting the potential of targeted contrast agents for diagnostic, mechanistic, and therapeutic studies." @default.
• W2117621180 created "2016-06-24" @default.
• W2117621180 creator A5003362859 @default.
• W2117621180 creator A5017098029 @default.
• W2117621180 creator A5027033084 @default.
• W2117621180 creator A5027668886 @default.
• W2117621180 creator A5043141098 @default.
• W2117621180 creator A5046617679 @default.
• W2117621180 creator A5049936296 @default.
• W2117621180 creator A5058725388 @default.
• W2117621180 creator A5076922893 @default.
• W2117621180 date "2008-02-01" @default.
• W2117621180 modified "2023-10-18" @default.
• W2117621180 title "A contrast agent recognizing activated platelets reveals murine cerebral malaria pathology undetectable by conventional MRI" @default.
• W2117621180 cites W1487287383 @default.
• W2117621180 cites W1908908549 @default.
• W2117621180 cites W1964062217 @default.
• W2117621180 cites W1979498341 @default.
• W2117621180 cites W1981864786 @default.
• W2117621180 cites W1988072585 @default.
• W2117621180 cites W1988113419 @default.
• W2117621180 cites W1990837240 @default.
• W2117621180 cites W1992496526 @default.
• W2117621180 cites W1993655373 @default.
• W2117621180 cites W1997995576 @default.
• W2117621180 cites W2008681019 @default.
• W2117621180 cites W2010075128 @default.
• W2117621180 cites W2013365435 @default.
• W2117621180 cites W2027763304 @default.
• W2117621180 cites W2031178652 @default.
• W2117621180 cites W2038030879 @default.
• W2117621180 cites W2042783871 @default.
• W2117621180 cites W2057023637 @default.
• W2117621180 cites W2064313651 @default.
• W2117621180 cites W2068151631 @default.
• W2117621180 cites W2075387072 @default.
• W2117621180 cites W2079986395 @default.
• W2117621180 cites W2085548371 @default.
• W2117621180 cites W2086550669 @default.
• W2117621180 cites W2093746762 @default.
• W2117621180 cites W2101037111 @default.
• W2117621180 cites W2107222316 @default.
• W2117621180 cites W2111066965 @default.
• W2117621180 cites W2122803681 @default.
• W2117621180 cites W2123568006 @default.
• W2117621180 cites W2134164686 @default.
• W2117621180 cites W2136302633 @default.
• W2117621180 cites W2139687653 @default.
• W2117621180 cites W2147796717 @default.
• W2117621180 cites W2154673060 @default.
• W2117621180 cites W2273675591 @default.
• W2117621180 cites W2413716832 @default.
• W2117621180 cites W2417418506 @default.
• W2117621180 cites W79640494 @default.
• W2117621180 doi "https://doi.org/10.1172/jci33314" @default.
• W2117621180 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2242620" @default.
• W2117621180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18274670" @default.
• W2117621180 hasPublicationYear "2008" @default.
• W2117621180 type Work @default.
• W2117621180 sameAs 2117621180 @default.
• W2117621180 citedByCount "31" @default.
• W2117621180 countsByYear W21176211802012 @default.
• W2117621180 countsByYear W21176211802014 @default.
• W2117621180 countsByYear W21176211802015 @default.
• W2117621180 countsByYear W21176211802016 @default.
• W2117621180 countsByYear W21176211802017 @default.
• W2117621180 countsByYear W21176211802018 @default.
• W2117621180 countsByYear W21176211802019 @default.
• W2117621180 countsByYear W21176211802020 @default.
• W2117621180 countsByYear W21176211802021 @default.
• W2117621180 countsByYear W21176211802022 @default.
• W2117621180 countsByYear W21176211802023 @default.
• W2117621180 crossrefType "journal-article" @default.
• W2117621180 hasAuthorship W2117621180A5003362859 @default.
• W2117621180 hasAuthorship W2117621180A5017098029 @default.
• W2117621180 hasAuthorship W2117621180A5027033084 @default.
• W2117621180 hasAuthorship W2117621180A5027668886 @default.
• W2117621180 hasAuthorship W2117621180A5043141098 @default.
• W2117621180 hasAuthorship W2117621180A5046617679 @default.
• W2117621180 hasAuthorship W2117621180A5049936296 @default.
• W2117621180 hasAuthorship W2117621180A5058725388 @default.
• W2117621180 hasAuthorship W2117621180A5076922893 @default.
• W2117621180 hasBestOaLocation W21176211801 @default.
• W2117621180 hasConcept C142724271 @default.
• W2117621180 hasConcept C164027704 @default.
• W2117621180 hasConcept C185592680 @default.
• W2117621180 hasConcept C203014093 @default.
• W2117621180 hasConcept C2776914184 @default.
• W2117621180 hasConcept C2777237215 @default.
• W2117621180 hasConcept C2778048844 @default.
• W2117621180 hasConcept C2778371730 @default.
• W2117621180 hasConcept C2779178360 @default.
• W2117621180 hasConcept C2908793570 @default.
• W2117621180 hasConcept C71924100 @default.
• W2117621180 hasConcept C86803240 @default.
• W2117621180 hasConcept C89560881 @default.
• W2117621180 hasConcept C95444343 @default.
• W2117621180 hasConceptScore W2117621180C142724271 @default.
• W2117621180 hasConceptScore W2117621180C164027704 @default.
• W2117621180 hasConceptScore W2117621180C185592680 @default.

• next