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• W2117629800 abstract "Controversy surrounds the role of the temporoparietal junction (TPJ) area of the human brain. Although TPJ has been implicated both in reorienting of attention and social cognition, it is still unclear whether these functions have the same neural basis. Indeed, whether TPJ is a precisely identifiable cortical region or a cluster of subregions with separate functions is still a matter of debate. Here, we examined the structural and functional connectivity of TPJ, testing whether TPJ is a unitary area with a heterogeneous functional connectivity profile or a conglomerate of regions with distinctive connectivity. Diffusion-weighted imaging tractrography–based parcellation identified 3 separate regions in TPJ. Resting-state functional connectivity was then used to establish which cortical networks each of these subregions participates in. A dorsal cluster in the middle part of the inferior parietal lobule showed resting-state functional connectivity with, among other areas, lateral anterior prefrontal cortex. Ventrally, an anterior TPJ cluster interacted with ventral prefrontal cortex and anterior insula, while a posterior TPJ cluster interacted with posterior cingulate, temporal pole, and anterior medial prefrontal cortex. These results indicate that TPJ can be subdivided into subregions on the basis of its structural and functional connectivity." @default.
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• W2117629800 date "2011-09-27" @default.
• W2117629800 modified "2023-10-11" @default.
• W2117629800 title "Connectivity-Based Subdivisions of the Human Right Temporoparietal Junction Area: Evidence for Different Areas Participating in Different Cortical Networks" @default.
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• W2117629800 doi "https://doi.org/10.1093/cercor/bhr268" @default.
• W2117629800 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21955921" @default.
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