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- W2117631881 abstract "In the present study, we examined the hypoglycemic properties and the effective mechanisms of a triterpenoid-rich extract from the Euryale shell (ES) in streptozotocin-induced (STZ) diabetic mice. The hydroalcoholic extract of ES (200, 400 and 600 mg/kg/day) was orally administered to STZ-diabetic mice for 4 weeks. We observed that in the liver of diabetic mice, the ES extract caused a sharp reduction in the gene expression of protein tyrosine phosphatase-1B (PTP1B) but induced the gene expression of phosphatidyl-inositol-3-kinase (PI-3K) and protein kinase B (PKB) compared with that of untreated diabetic mice. Additionally, a significant increase in the phosphorylation of the PKB protein was observed (p<0.01). This was corroborated by the inhibition of PTP1B and by the regulation of glucose uptake via PI-3K activation, which together demonstrate that the reduction of PTP1B can modulate key insulin signaling events downstream of the insulin receptor." @default.
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- W2117631881 date "2013-05-13" @default.
- W2117631881 modified "2023-09-27" @default.
- W2117631881 title "Hypoglycemic activity and the activation of phosphorylation of a triterpenoid-rich extract from Euryale shell on streptozotocin-induced diabetic mice" @default.
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- W2117631881 doi "https://doi.org/10.3329/bjp.v8i3.14718" @default.
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