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- W2117645485 abstract "To identify a panel of biomarkers that predicts response of esophageal cancers to preoperative chemoradiation, our group profiled the gene expression of pretreatment cancer biopsies from patients with esophageal cancer. Six (32%) of these patients had pathologic complete response. All cancers except one that achieved pathologic complete response (83%) clustered in one molecular type (type I), while cancers that achieved less than pathologic complete response with one exception clustered in another molecular type (type II). Activated NF-kappaB was significantly associated with aggressive pathology. These data indicate that expression analysis of a limited set of biomarkers selected from the list of genes that were differentially regulated between the two subtypes can increase predictive power, and suggest that esophageal cancer with activated NF-kappaB may result in poor treatment outcome." @default.
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- W2117645485 date "2006-12-01" @default.
- W2117645485 modified "2023-09-27" @default.
- W2117645485 title "Biomarkers of Response to Preoperative Chemoradiation in Esophageal Cancers" @default.
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- W2117645485 doi "https://doi.org/10.1053/j.seminoncol.2006.10.004" @default.
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