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• W2117656056 abstract "Recent advances reported the probable priority of vascular and its secretory profile changes in pathogenesis of radiation myelopathy (RM). Vascular hypothesis states that vascular changes occur prior to any alterations in the white matter parenchyma possibly due to low dose radiosensitivity of vascular endothelium (1, 2). Modern enzymatic and/or immunohistochemical techniques have been applied to animal models for studying the radiation-induced changes in the various biochemical mediators produced by different cells within the irradiated medium (2). Prostacyclin in vitro measurement has shown its alteration shortly after low dose irradiation. Prostaglandins (PGs) have applications in diagnosis of different spinal cord disorders in a range from cerebrospinal fluid to intra spinal antibody microprobes or spinal cord homogenates. A basal level of PGs may exist in many laboratory samples and it is believed that injury to tissue induces release of prostaglandins (3). The possibility of the eicosanoids role in development of radiation toxicities have been reported by other investigations (3-7). More recent studies have also shown that some prostaglandins are responsive to irradiation and their early changes can induce the late reactions of spinal cord so called radiation myelopathy (3, 8, 9). Purpose of this article is to study the model of prostaglandin I2 (PGI2) or prostacyclin concentration changes in response to the low doses of X-irradiation after a short period of time. Background: Study of vascular and its secretory profile changes is an important issue in pathogenesis of radiation myelopathy. This paper reports the prostacyclin concentration changes after lowmoderate doses of X-irradiation within a short period of time. Materials and Methods: Cervical cords of Wistar rats were irradiated to doses of 0.5, 1, 2, 4 and 6 Gy X-rays. After 24 hours, 2 and 13 weeks postirradiation, prostacyclin contents were quantified and cords specimens were also stained routinely for histological studies. Results: Twenty four hours postirradiation, showed a decrease in the content of prostacyclin after doses of 0.5 and 1 Gy 91.67±1.47% 96.80±2.17% of respectively age-matched control group. After 2 weeks the concentration of prostacyclin showed significant decreases after 6 Gy. After 13 weeks irradiation shows marked differences even after a small dose of 2 Gy (p<0.001), and after doses of the low dose group. The differences between concentration values at doses of 4 Gy and 6 Gy were significant in comparison with the control (p<0.001 and p<0.002, respectively). Conclusion: Results suggested that the response of the vascular tissues to low and moderate doses of radiation occurs prior to that of the nervous tissue of the spinal cord. It means that the asymptomatic interval after radiation is characterized by sequential physiological changes which are imperfectly reflected in routine histological study and that even in the histologically unaffected spinal cord; severe impairment is present in substructures and biochemistry of irradiated spinal cord. Iran. J. Radiat. Res., 2006; 4 (3): 129-136" @default.
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• W2117656056 date "2006-12-15" @default.
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• W2117656056 title "Chronological response of prostacyclin changes to moderately low doses of radiation in Rat cervical spinal cord" @default.
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