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• W2117659720 startingPage "144" @default.
• W2117659720 abstract "OBJECTIVES: Platelet‐derived growth factor (PDGF)‐BB is a polypeptide growth factor which has been shown to stimulate periodontal regeneration. In this study, we investigated the time‐ and dose‐dependent effect of PDGF‐BB on the proliferation and collagen synthesis of human periodontal ligament (PDL) cells. MATERIALS AND METHODS: For the proliferation assay, PDL cells were cultured in 0.01–10 ng ml −1 of PDGF‐BB for 12 or 24 h, and cell numbers were counted. For the collagen synthesis assay, PDL cells were cultured in 0.1–10 ng ml −1 of PDGF‐BB for 1 to 24 h. The ratio of collagen content in total protein was evaluated, and the gene expression of type I collagen was assessed quantitatively by Northern blotting analysis. RESULT AND CONCLUSIONS: PDGF‐BB stimulated the proliferation of PDL cells in a time‐ and dose‐dependent manner with the maximum effect at 10 ng ml −1 . PDGF‐BB induced the collagen synthesis of PDL cells with the maximum effect for 24‐h treatment, and 1 ng ml −1 of PDGF‐BB. PDGF‐BB exhibits an inverse dose‐dependent effect on proliferation and collagen synthesis by PDL cells. These findings suggest that PDGF‐BB is one of the important regulators of the maintenance of the extracellular matrix in PDL, and may play an important role in the regeneration of PDL." @default.
• W2117659720 created "2016-06-24" @default.
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• W2117659720 date "2003-05-01" @default.
• W2117659720 modified "2023-10-15" @default.
• W2117659720 title "<i>In vitro</i>effect of platelet-derived growth factor-BB on collagen synthesis and proliferation of human periodontal ligament cells" @default.
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• W2117659720 doi "https://doi.org/10.1034/j.1601-0825.2003.02906.x" @default.
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