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• W2117660299 abstract "Abstract Genetic screens in Drosophila melanogaster and other organisms have been pursued to filter the genome for genetic functions important for memory formation. Such screens have employed primarily chemical or transposon-mediated mutagenesis and have identified numerous mutants including classical memory mutants, dunce and rutabaga. Here, we report the results of a large screen using panneuronal RNAi expression to identify additional genes critical for memory formation. We identified &gt;500 genes that compromise memory when inhibited (low hits), either by disrupting the development and normal function of the adult animal or by participating in the neurophysiological mechanisms underlying memory formation. We also identified &gt;40 genes that enhance memory when inhibited (high hits). The dunce gene was identified as one of the low hits and further experiments were performed to map the effects of the dunce RNAi to the α/β and γ mushroom body neurons. Additional behavioral experiments suggest that dunce knockdown in the mushroom body neurons impairs memory without significantly affecting acquisition. We also characterized one high hit, sickie, to show that RNAi knockdown of this gene enhances memory through effects in dopaminergic neurons without apparent effects on acquisition. These studies further our understanding of two genes involved in memory formation, provide a valuable list of genes that impair memory that may be important for understanding the neurophysiology of memory or neurodevelopmental disorders, and offer a new resource of memory suppressor genes that will aid in understanding restraint mechanisms employed by the brain to optimize resources." @default.
• W2117660299 created "2016-06-24" @default.
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• W2117660299 date "2015-02-02" @default.
• W2117660299 modified "2023-10-15" @default.
• W2117660299 title "Identification of Genes That Promote or Inhibit Olfactory Memory Formation in <i>Drosophila</i>" @default.
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• W2117660299 doi "https://doi.org/10.1534/genetics.114.173575" @default.
• W2117660299 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4391555" @default.
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