Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117671645> ?p ?o ?g. }
- W2117671645 endingPage "1238" @default.
- W2117671645 startingPage "1230" @default.
- W2117671645 abstract "Traditional categorization of theories of aging into programmed and stochastic ones is outdated and obsolete. Biological aging is considered to occur mainly during the period of survival beyond the natural or essential lifespan (ELS) in Darwinian terms. Organisms survive to achieve ELS by virtue of genetically determined longevity assuring maintenance and repair systems (MRS). Aging at the molecular level is characterized by the progressive accumulation of molecular damage caused by environmental and metabolically generated free radicals, by spontaneous errors in biochemical reactions, and by nutritional components. Damages in the MRS and other pathways lead to age-related failure of MRS, molecular heterogeneity, cellular dysfunctioning, reduced stress tolerance, diseases and ultimate death. A unified theory of biological aging in terms of failure of homeodynamics comprising of MRS, and involving genes, milieu and chance, is acquiring a definitive shape and wider acceptance. Such a theory also establishes the basis for testing and developing effective means of intervention, prevention and modulation of aging." @default.
- W2117671645 created "2016-06-24" @default.
- W2117671645 creator A5081203519 @default.
- W2117671645 date "2006-01-01" @default.
- W2117671645 modified "2023-10-17" @default.
- W2117671645 title "Theories of biological aging: Genes, proteins, and free radicals" @default.
- W2117671645 cites W107588719 @default.
- W2117671645 cites W113943951 @default.
- W2117671645 cites W1491750629 @default.
- W2117671645 cites W1530924711 @default.
- W2117671645 cites W1539895469 @default.
- W2117671645 cites W1547383512 @default.
- W2117671645 cites W1548504211 @default.
- W2117671645 cites W1582948192 @default.
- W2117671645 cites W1602232100 @default.
- W2117671645 cites W1650427240 @default.
- W2117671645 cites W17453112 @default.
- W2117671645 cites W175936796 @default.
- W2117671645 cites W1844286590 @default.
- W2117671645 cites W1951314249 @default.
- W2117671645 cites W1963997407 @default.
- W2117671645 cites W1972958434 @default.
- W2117671645 cites W1975955767 @default.
- W2117671645 cites W1976070906 @default.
- W2117671645 cites W1976130719 @default.
- W2117671645 cites W1978175417 @default.
- W2117671645 cites W1978340010 @default.
- W2117671645 cites W1981934489 @default.
- W2117671645 cites W1982149922 @default.
- W2117671645 cites W1983025747 @default.
- W2117671645 cites W1983410328 @default.
- W2117671645 cites W1987305776 @default.
- W2117671645 cites W1993464125 @default.
- W2117671645 cites W1998026347 @default.
- W2117671645 cites W2001082461 @default.
- W2117671645 cites W2002412338 @default.
- W2117671645 cites W2005313335 @default.
- W2117671645 cites W2011635175 @default.
- W2117671645 cites W2012915699 @default.
- W2117671645 cites W2013039918 @default.
- W2117671645 cites W2014218268 @default.
- W2117671645 cites W2015607124 @default.
- W2117671645 cites W2021217216 @default.
- W2117671645 cites W2022572059 @default.
- W2117671645 cites W2027838121 @default.
- W2117671645 cites W2029070164 @default.
- W2117671645 cites W2031454887 @default.
- W2117671645 cites W2031590848 @default.
- W2117671645 cites W2035045145 @default.
- W2117671645 cites W2036103078 @default.
- W2117671645 cites W2036217493 @default.
- W2117671645 cites W2040392874 @default.
- W2117671645 cites W2041417631 @default.
- W2117671645 cites W2047638068 @default.
- W2117671645 cites W2049165621 @default.
- W2117671645 cites W2052899770 @default.
- W2117671645 cites W2053660330 @default.
- W2117671645 cites W2058913657 @default.
- W2117671645 cites W2063631906 @default.
- W2117671645 cites W2066170631 @default.
- W2117671645 cites W2071695898 @default.
- W2117671645 cites W2075815316 @default.
- W2117671645 cites W2076176960 @default.
- W2117671645 cites W2077605867 @default.
- W2117671645 cites W2081878182 @default.
- W2117671645 cites W2085728684 @default.
- W2117671645 cites W2089941945 @default.
- W2117671645 cites W2092279282 @default.
- W2117671645 cites W2095252240 @default.
- W2117671645 cites W2095415425 @default.
- W2117671645 cites W2097952463 @default.
- W2117671645 cites W2100598897 @default.
- W2117671645 cites W2102568183 @default.
- W2117671645 cites W2105754268 @default.
- W2117671645 cites W2110775830 @default.
- W2117671645 cites W2114262875 @default.
- W2117671645 cites W2116844947 @default.
- W2117671645 cites W2120878665 @default.
- W2117671645 cites W2128188444 @default.
- W2117671645 cites W2132211535 @default.
- W2117671645 cites W2132398264 @default.
- W2117671645 cites W2133425142 @default.
- W2117671645 cites W2134454718 @default.
- W2117671645 cites W2136492640 @default.
- W2117671645 cites W2137048190 @default.
- W2117671645 cites W2138708553 @default.
- W2117671645 cites W2150080365 @default.
- W2117671645 cites W2151426881 @default.
- W2117671645 cites W2154013195 @default.
- W2117671645 cites W2163570079 @default.
- W2117671645 cites W2166025606 @default.
- W2117671645 cites W2170138349 @default.
- W2117671645 cites W2190457762 @default.
- W2117671645 cites W220991252 @default.
- W2117671645 cites W2336883106 @default.
- W2117671645 cites W2986902493 @default.
- W2117671645 cites W3023167551 @default.
- W2117671645 cites W328594642 @default.