Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117675603> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2117675603 endingPage "141" @default.
- W2117675603 startingPage "133" @default.
- W2117675603 abstract "The antithyroid drug, methimazole, was investigated to assess its potential as a positive control agent in developmental behavioral studies. Methimazole was administered in drinking water to dams from the 17th gestational day to the 10th postnatal day. Methimazole treatment produced developmental delays and motor deficits in offspring tested in a behavioral battery assessing development of sensory and motor function. Acquisition of a righting response was delayed 7 days, from postnatal Day 7 in controls to Day 14 in treated rats; the appearance of the auditory startle response was delayed 6 days, from Day 12 to Day 18; the time of eye opening was delayed 2 days, from Day 15 to Day 17. A deficit, rather than a delay, was observed in body weight gain and in a reflex-suspension test of motor development. Treated rats showed decreased exploratory activity in an open field at postnatal Day 21 compared with controls. It was concluded that developmental test batteries, such as those proposed to screen for neurobehavioral toxicity, may readily detect neurotoxic damage from goitrogens. The convenience of methimazole administration in drinking water plus the efficacy of methimazole inducing developmental deficits and delays suggests this agent may be an effective positive control in developmental behavioral test batteries." @default.
- W2117675603 created "2016-06-24" @default.
- W2117675603 creator A5059636658 @default.
- W2117675603 creator A5089254241 @default.
- W2117675603 date "1982-03-01" @default.
- W2117675603 modified "2023-09-27" @default.
- W2117675603 title "Effects of perinatal methimazole exposure on a developmental test battery for neurobehavioral toxicity in rats" @default.
- W2117675603 cites W1553146631 @default.
- W2117675603 cites W1968194268 @default.
- W2117675603 cites W1971547364 @default.
- W2117675603 cites W1976662119 @default.
- W2117675603 cites W1993216890 @default.
- W2117675603 cites W1999979999 @default.
- W2117675603 cites W2000069828 @default.
- W2117675603 cites W2003713709 @default.
- W2117675603 cites W2026597414 @default.
- W2117675603 cites W2028637688 @default.
- W2117675603 cites W2037509657 @default.
- W2117675603 cites W2037816833 @default.
- W2117675603 cites W2048074668 @default.
- W2117675603 cites W2049841307 @default.
- W2117675603 cites W2050988071 @default.
- W2117675603 cites W2051274642 @default.
- W2117675603 cites W2081428944 @default.
- W2117675603 cites W2127569484 @default.
- W2117675603 cites W2162843814 @default.
- W2117675603 cites W2332724484 @default.
- W2117675603 cites W2411564279 @default.
- W2117675603 doi "https://doi.org/10.1016/0041-008x(82)90032-1" @default.
- W2117675603 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7071868" @default.
- W2117675603 hasPublicationYear "1982" @default.
- W2117675603 type Work @default.
- W2117675603 sameAs 2117675603 @default.
- W2117675603 citedByCount "55" @default.
- W2117675603 countsByYear W21176756032012 @default.
- W2117675603 countsByYear W21176756032013 @default.
- W2117675603 countsByYear W21176756032015 @default.
- W2117675603 countsByYear W21176756032017 @default.
- W2117675603 countsByYear W21176756032018 @default.
- W2117675603 countsByYear W21176756032021 @default.
- W2117675603 countsByYear W21176756032022 @default.
- W2117675603 crossrefType "journal-article" @default.
- W2117675603 hasAuthorship W2117675603A5059636658 @default.
- W2117675603 hasAuthorship W2117675603A5089254241 @default.
- W2117675603 hasConcept C112672928 @default.
- W2117675603 hasConcept C126322002 @default.
- W2117675603 hasConcept C131783052 @default.
- W2117675603 hasConcept C134018914 @default.
- W2117675603 hasConcept C15744967 @default.
- W2117675603 hasConcept C179335377 @default.
- W2117675603 hasConcept C2776417830 @default.
- W2117675603 hasConcept C2779085643 @default.
- W2117675603 hasConcept C2779234561 @default.
- W2117675603 hasConcept C29730261 @default.
- W2117675603 hasConcept C42407357 @default.
- W2117675603 hasConcept C46973012 @default.
- W2117675603 hasConcept C526584372 @default.
- W2117675603 hasConcept C54355233 @default.
- W2117675603 hasConcept C71924100 @default.
- W2117675603 hasConcept C83974742 @default.
- W2117675603 hasConcept C86803240 @default.
- W2117675603 hasConceptScore W2117675603C112672928 @default.
- W2117675603 hasConceptScore W2117675603C126322002 @default.
- W2117675603 hasConceptScore W2117675603C131783052 @default.
- W2117675603 hasConceptScore W2117675603C134018914 @default.
- W2117675603 hasConceptScore W2117675603C15744967 @default.
- W2117675603 hasConceptScore W2117675603C179335377 @default.
- W2117675603 hasConceptScore W2117675603C2776417830 @default.
- W2117675603 hasConceptScore W2117675603C2779085643 @default.
- W2117675603 hasConceptScore W2117675603C2779234561 @default.
- W2117675603 hasConceptScore W2117675603C29730261 @default.
- W2117675603 hasConceptScore W2117675603C42407357 @default.
- W2117675603 hasConceptScore W2117675603C46973012 @default.
- W2117675603 hasConceptScore W2117675603C526584372 @default.
- W2117675603 hasConceptScore W2117675603C54355233 @default.
- W2117675603 hasConceptScore W2117675603C71924100 @default.
- W2117675603 hasConceptScore W2117675603C83974742 @default.
- W2117675603 hasConceptScore W2117675603C86803240 @default.
- W2117675603 hasIssue "1" @default.
- W2117675603 hasLocation W21176756031 @default.
- W2117675603 hasLocation W21176756032 @default.
- W2117675603 hasOpenAccess W2117675603 @default.
- W2117675603 hasPrimaryLocation W21176756031 @default.
- W2117675603 hasRelatedWork W1984669348 @default.
- W2117675603 hasRelatedWork W1989062816 @default.
- W2117675603 hasRelatedWork W2045473338 @default.
- W2117675603 hasRelatedWork W2064695746 @default.
- W2117675603 hasRelatedWork W2076442590 @default.
- W2117675603 hasRelatedWork W2110681150 @default.
- W2117675603 hasRelatedWork W2172122750 @default.
- W2117675603 hasRelatedWork W2322374245 @default.
- W2117675603 hasRelatedWork W2469048489 @default.
- W2117675603 hasRelatedWork W2748952813 @default.
- W2117675603 hasVolume "63" @default.
- W2117675603 isParatext "false" @default.
- W2117675603 isRetracted "false" @default.
- W2117675603 magId "2117675603" @default.
- W2117675603 workType "article" @default.