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- W2117714066 abstract "The effects of dietary supplementation with ammonium tetrathiotungstate and dithiotungstate on copper metabolism in young rats have been investigated. The addition of WS42− (4–32 mg W/kg diet) decreased growth rates and induced clinical and biochemical signs of Cu deficiency. These were overcome by increasing the dietary content of Cu. The intestinal absorption of 64Cu was impaired and the tissue distribution of absorbed Cu modified by the administration of WS42−. No clinical or biochemical detects indicative of Cu deficiency developed in rats receiving WO2S22− in their diet at concentrations up to 32 mg W/kg. In contrast, this oxythioanion enhanced the content of Cu in plasma liver and kidney, especially when dietary Cu was increased. Most of the additional Cu retained by plasma and kidney was associated with albumin and metallothionein, respectively. The effects of these W sources are compared with those caused by their thio- and oxythiomolybdate analogs and are discussed in relation to the mechanisms whereby Mo induces Cu deficiency in ruminants." @default.
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- W2117714066 date "1982-01-01" @default.
- W2117714066 modified "2023-10-18" @default.
- W2117714066 title "Effects of tetrathiotungstate and dithiotungstate on copper metabolism in rats" @default.
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- W2117714066 doi "https://doi.org/10.1016/s0162-0134(00)80220-2" @default.
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