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• W2117723622 endingPage "23" @default.
• W2117723622 startingPage "1" @default.
• W2117723622 abstract "Transcriptional regulation of gene expression plays a significant role in establishing the diversity of human cell types and biological functions from a common set of genes. The components of regulatory control in the human genome include cis-acting elements that act across immense genomic distances to influence the spatial and temporal distribution of gene expression. Here we review the established categories of distant-acting regulatory elements, discussing the classical and contemporary evidence of their regulatory potential and clinical importance. Current efforts to identify regulatory sequences throughout the genome and elucidate their biological significance depend heavily on advances in sequence conservation–based analyses and on increasingly large-scale efforts applying transgenic technologies in model organisms. We discuss the advantages and limitations of sequence conservation as a predictor of regulatory function and present complementary emerging technologies now being applied to annotate regulatory elements in vertebrate genomes." @default.
• W2117723622 created "2016-06-24" @default.
• W2117723622 creator A5021277023 @default.
• W2117723622 creator A5054736588 @default.
• W2117723622 date "2010-09-01" @default.
• W2117723622 modified "2023-10-16" @default.
• W2117723622 title "Genomics of Long-Range Regulatory Elements" @default.
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