FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117737648> ?p ?o ?g. }

• W2117737648 endingPage "574" @default.
• W2117737648 startingPage "571" @default.
• W2117737648 abstract "The dynamics of adaptation determine which mutations fix in a population, and hence how reproducible evolution will be. This is central to understanding the spectra of mutations recovered in the evolution of antibiotic resistance, the response of pathogens to immune selection, and the dynamics of cancer progression. In laboratory evolution experiments, demonstrably beneficial mutations are found repeatedly, but are often accompanied by other mutations with no obvious benefit. Here we use whole-genome whole-population sequencing to examine the dynamics of genome sequence evolution at high temporal resolution in 40 replicate Saccharomyces cerevisiae populations growing in rich medium for 1,000 generations. We find pervasive genetic hitchhiking: multiple mutations arise and move synchronously through the population as mutational 'cohorts'. Multiple clonal cohorts are often present simultaneously, competing with each other in the same population. Our results show that patterns of sequence evolution are driven by a balance between these chance effects of hitchhiking and interference, which increase stochastic variation in evolutionary outcomes, and the deterministic action of selection on individual mutations, which favours parallel evolutionary solutions in replicate populations." @default.
• W2117737648 created "2016-06-24" @default.
• W2117737648 creator A5025910539 @default.
• W2117737648 creator A5051640845 @default.
• W2117737648 creator A5052546138 @default.
• W2117737648 creator A5060606796 @default.
• W2117737648 creator A5061501695 @default.
• W2117737648 creator A5068171806 @default.
• W2117737648 creator A5077542898 @default.
• W2117737648 date "2013-07-21" @default.
• W2117737648 modified "2023-10-10" @default.
• W2117737648 title "Pervasive genetic hitchhiking and clonal interference in forty evolving yeast populations" @default.
• W2117737648 cites W1813843188 @default.
• W2117737648 cites W1955582561 @default.
• W2117737648 cites W1988057380 @default.
• W2117737648 cites W2006492816 @default.
• W2117737648 cites W2012766690 @default.
• W2117737648 cites W2015249637 @default.
• W2117737648 cites W2016168002 @default.
• W2117737648 cites W2016666153 @default.
• W2117737648 cites W2021341670 @default.
• W2117737648 cites W2023337212 @default.
• W2117737648 cites W2023560061 @default.
• W2117737648 cites W2031581341 @default.
• W2117737648 cites W2055043387 @default.
• W2117737648 cites W2057017576 @default.
• W2117737648 cites W2059707355 @default.
• W2117737648 cites W2077214326 @default.
• W2117737648 cites W2085896397 @default.
• W2117737648 cites W2090437685 @default.
• W2117737648 cites W2096160674 @default.
• W2117737648 cites W2103441770 @default.
• W2117737648 cites W2108234281 @default.
• W2117737648 cites W2109991075 @default.
• W2117737648 cites W2116701298 @default.
• W2117737648 cites W2117131162 @default.
• W2117737648 cites W2123805784 @default.
• W2117737648 cites W2128099419 @default.
• W2117737648 cites W2128327734 @default.
• W2117737648 cites W2130757930 @default.
• W2117737648 cites W2143598835 @default.
• W2117737648 cites W2152177323 @default.
• W2117737648 cites W2152749315 @default.
• W2117737648 cites W2154279044 @default.
• W2117737648 cites W2170568588 @default.
• W2117737648 cites W2171900790 @default.
• W2117737648 cites W4295837538 @default.
• W2117737648 doi "https://doi.org/10.1038/nature12344" @default.
• W2117737648 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3758440" @default.
• W2117737648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23873039" @default.
• W2117737648 hasPublicationYear "2013" @default.
• W2117737648 type Work @default.
• W2117737648 sameAs 2117737648 @default.
• W2117737648 citedByCount "524" @default.
• W2117737648 countsByYear W21177376482013 @default.
• W2117737648 countsByYear W21177376482014 @default.
• W2117737648 countsByYear W21177376482015 @default.
• W2117737648 countsByYear W21177376482016 @default.
• W2117737648 countsByYear W21177376482017 @default.
• W2117737648 countsByYear W21177376482018 @default.
• W2117737648 countsByYear W21177376482019 @default.
• W2117737648 countsByYear W21177376482020 @default.
• W2117737648 countsByYear W21177376482021 @default.
• W2117737648 countsByYear W21177376482022 @default.
• W2117737648 countsByYear W21177376482023 @default.
• W2117737648 crossrefType "journal-article" @default.
• W2117737648 hasAuthorship W2117737648A5025910539 @default.
• W2117737648 hasAuthorship W2117737648A5051640845 @default.
• W2117737648 hasAuthorship W2117737648A5052546138 @default.
• W2117737648 hasAuthorship W2117737648A5060606796 @default.
• W2117737648 hasAuthorship W2117737648A5061501695 @default.
• W2117737648 hasAuthorship W2117737648A5068171806 @default.
• W2117737648 hasAuthorship W2117737648A5077542898 @default.
• W2117737648 hasBestOaLocation W21177376482 @default.
• W2117737648 hasConcept C104317684 @default.
• W2117737648 hasConcept C105795698 @default.
• W2117737648 hasConcept C139807058 @default.
• W2117737648 hasConcept C141231307 @default.
• W2117737648 hasConcept C144024400 @default.
• W2117737648 hasConcept C149129301 @default.
• W2117737648 hasConcept C149923435 @default.
• W2117737648 hasConcept C154945302 @default.
• W2117737648 hasConcept C1570309 @default.
• W2117737648 hasConcept C169760540 @default.
• W2117737648 hasConcept C171578705 @default.
• W2117737648 hasConcept C24432333 @default.
• W2117737648 hasConcept C2781162219 @default.
• W2117737648 hasConcept C2908647359 @default.
• W2117737648 hasConcept C33923547 @default.
• W2117737648 hasConcept C41008148 @default.
• W2117737648 hasConcept C501734568 @default.
• W2117737648 hasConcept C54355233 @default.
• W2117737648 hasConcept C78458016 @default.
• W2117737648 hasConcept C81917197 @default.
• W2117737648 hasConcept C86803240 @default.
• W2117737648 hasConcept C87590526 @default.
• W2117737648 hasConcept C8769409 @default.
• W2117737648 hasConcept C98638677 @default.

• next