Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117744574> ?p ?o ?g. }
- W2117744574 endingPage "179" @default.
- W2117744574 startingPage "173" @default.
- W2117744574 abstract "The current study was carried out to investigate the cognitive effects of two serotonin reuptake inhibitors (SSRIs), sertraline and paroxetine, with special reference to differences in their affinity for other neurotransmitter systems, i.e. anticholinergic activity of paroxetine and putative dopamine reuptake activity of sertraline. The study was conducted according to a double-blind, three-way cross-over design. During three treatment periods of 2 weeks, 24 healthy middle-aged (aged 30-50 years) subjects of both sexes received sertraline (50 mg on days 1-7, 100 mg on days 8-14), paroxetine (20 mg on days 1-7, 40 mg on days 8-14) and placebo. Paroxetine specifically impaired delayed recall in a word learning test at a dose of 20 and 40 mg. Sertraline did not affect word learning but improved performance on a verbal fluency task at a dose of 50 and 100 mg. Neither drug affected performance on a short-term memory scanning task. These subtle but significant changes in cognitive performance can be explained by subtle differences in pharmacological profiles of these SSRIs. The additional anticholinergic effects of paroxetine could account for its induction of long-term memory impairment. Similarly, the additional dopaminergic effects of sertraline could account for its induction of slightly improved verbal fluency. The impairing and facilitating cognitive effects of paroxetine and sertraline, respectively, may be more pronounced in the elderly depressed patient." @default.
- W2117744574 created "2016-06-24" @default.
- W2117744574 creator A5015373547 @default.
- W2117744574 creator A5027095561 @default.
- W2117744574 creator A5062066656 @default.
- W2117744574 date "2001-05-01" @default.
- W2117744574 modified "2023-10-18" @default.
- W2117744574 title "Non-serotonergic pharmacological profiles and associated cognitive effects of serotonin reuptake inhibitors" @default.
- W2117744574 cites W1657936130 @default.
- W2117744574 cites W1878275568 @default.
- W2117744574 cites W1963545345 @default.
- W2117744574 cites W1965911022 @default.
- W2117744574 cites W1967499832 @default.
- W2117744574 cites W1968268022 @default.
- W2117744574 cites W1977634040 @default.
- W2117744574 cites W1979293025 @default.
- W2117744574 cites W1980619435 @default.
- W2117744574 cites W1991561949 @default.
- W2117744574 cites W1995677537 @default.
- W2117744574 cites W1999745788 @default.
- W2117744574 cites W2005226124 @default.
- W2117744574 cites W2013893908 @default.
- W2117744574 cites W2014429887 @default.
- W2117744574 cites W2015827110 @default.
- W2117744574 cites W2019381424 @default.
- W2117744574 cites W2025947449 @default.
- W2117744574 cites W2030128523 @default.
- W2117744574 cites W2030786840 @default.
- W2117744574 cites W2038237232 @default.
- W2117744574 cites W2042520859 @default.
- W2117744574 cites W2050203654 @default.
- W2117744574 cites W2051376367 @default.
- W2117744574 cites W2060811322 @default.
- W2117744574 cites W2066610947 @default.
- W2117744574 cites W2067451952 @default.
- W2117744574 cites W2068284153 @default.
- W2117744574 cites W2069100239 @default.
- W2117744574 cites W2071509654 @default.
- W2117744574 cites W2073366799 @default.
- W2117744574 cites W2075469431 @default.
- W2117744574 cites W2075862832 @default.
- W2117744574 cites W2076399815 @default.
- W2117744574 cites W2076513227 @default.
- W2117744574 cites W2076639163 @default.
- W2117744574 cites W2084193392 @default.
- W2117744574 cites W2087189693 @default.
- W2117744574 cites W2095253451 @default.
- W2117744574 cites W2104583974 @default.
- W2117744574 cites W2109281404 @default.
- W2117744574 cites W2114083018 @default.
- W2117744574 cites W2127538073 @default.
- W2117744574 cites W2128720831 @default.
- W2117744574 cites W2131366636 @default.
- W2117744574 cites W2170332928 @default.
- W2117744574 doi "https://doi.org/10.1177/026988110101500304" @default.
- W2117744574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11565624" @default.
- W2117744574 hasPublicationYear "2001" @default.
- W2117744574 type Work @default.
- W2117744574 sameAs 2117744574 @default.
- W2117744574 citedByCount "107" @default.
- W2117744574 countsByYear W21177445742012 @default.
- W2117744574 countsByYear W21177445742013 @default.
- W2117744574 countsByYear W21177445742014 @default.
- W2117744574 countsByYear W21177445742015 @default.
- W2117744574 countsByYear W21177445742017 @default.
- W2117744574 countsByYear W21177445742018 @default.
- W2117744574 countsByYear W21177445742019 @default.
- W2117744574 countsByYear W21177445742020 @default.
- W2117744574 countsByYear W21177445742021 @default.
- W2117744574 countsByYear W21177445742022 @default.
- W2117744574 crossrefType "journal-article" @default.
- W2117744574 hasAuthorship W2117744574A5015373547 @default.
- W2117744574 hasAuthorship W2117744574A5027095561 @default.
- W2117744574 hasAuthorship W2117744574A5062066656 @default.
- W2117744574 hasConcept C118552586 @default.
- W2117744574 hasConcept C126322002 @default.
- W2117744574 hasConcept C137183658 @default.
- W2117744574 hasConcept C14216870 @default.
- W2117744574 hasConcept C15744967 @default.
- W2117744574 hasConcept C169760540 @default.
- W2117744574 hasConcept C169900460 @default.
- W2117744574 hasConcept C170493617 @default.
- W2117744574 hasConcept C2775864247 @default.
- W2117744574 hasConcept C2777669559 @default.
- W2117744574 hasConcept C2777828372 @default.
- W2117744574 hasConcept C2778689640 @default.
- W2117744574 hasConcept C2779177272 @default.
- W2117744574 hasConcept C2780092697 @default.
- W2117744574 hasConcept C31487548 @default.
- W2117744574 hasConcept C37000724 @default.
- W2117744574 hasConcept C42219234 @default.
- W2117744574 hasConcept C513476851 @default.
- W2117744574 hasConcept C558461103 @default.
- W2117744574 hasConcept C71924100 @default.
- W2117744574 hasConcept C97530452 @default.
- W2117744574 hasConcept C98274493 @default.
- W2117744574 hasConceptScore W2117744574C118552586 @default.
- W2117744574 hasConceptScore W2117744574C126322002 @default.