Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117746168> ?p ?o ?g. }
- W2117746168 endingPage "554" @default.
- W2117746168 startingPage "544" @default.
- W2117746168 abstract "Blockade of the renin-angiotensin system (RAS) with angiotensin I-converting enzyme (ACE) inhibitors and AT1-receptor (AT1R) blockers has become one of the most successful therapeutic approaches in medicine. The question is no longer whether RAS inhibition helps, but rather how we can optimize inhibition to achieve optimal cardiovascular and renal protection. Indeed, numerous data have shown that the RAS is not blocked fully over 24 hours with current doses of RAS blockers because they trigger a counter-regulatory renin release that can offset pharmacologic inhibition of the RAS. This absence of full blockade may have clinical implications. Combination therapy with ACE inhibitors and AT1R antagonists thus has been proposed to inhibit the biological effects of the reactive renin release triggered by single-site RAS inhibition. By using this approach, numerous experimental and clinical studies have suggested that this combination therapy has additive or synergistic effects on blood pressure and on the prevention of cardiovascular and renal lesions. Although similar intensity of RAS blockade can be achieved by either combination therapy or by using high doses of an AT1-receptor antagonist given alone, the ACE inhibitor present in the combination interferes with the bradykinin-nitric oxide pathway and the N-acetyl-Ser-Asp-Lys-Pro metabolism, which both may have additional biological effects." @default.
- W2117746168 created "2016-06-24" @default.
- W2117746168 creator A5056380138 @default.
- W2117746168 creator A5059403921 @default.
- W2117746168 date "2007-09-01" @default.
- W2117746168 modified "2023-10-01" @default.
- W2117746168 title "Rationale for Combining Blockers of the Renin-Angiotensin System" @default.
- W2117746168 cites W1497461844 @default.
- W2117746168 cites W1521804991 @default.
- W2117746168 cites W1541017615 @default.
- W2117746168 cites W1592471891 @default.
- W2117746168 cites W1594509828 @default.
- W2117746168 cites W1604542334 @default.
- W2117746168 cites W180946569 @default.
- W2117746168 cites W1968506132 @default.
- W2117746168 cites W1970281455 @default.
- W2117746168 cites W1972221458 @default.
- W2117746168 cites W1974174019 @default.
- W2117746168 cites W1979771115 @default.
- W2117746168 cites W1983486737 @default.
- W2117746168 cites W1994332748 @default.
- W2117746168 cites W2001722069 @default.
- W2117746168 cites W2003350706 @default.
- W2117746168 cites W2006999079 @default.
- W2117746168 cites W2008163059 @default.
- W2117746168 cites W2011662228 @default.
- W2117746168 cites W2012944839 @default.
- W2117746168 cites W2014739371 @default.
- W2117746168 cites W2014795889 @default.
- W2117746168 cites W2018312583 @default.
- W2117746168 cites W2021011733 @default.
- W2117746168 cites W2023755744 @default.
- W2117746168 cites W2025439636 @default.
- W2117746168 cites W2026232111 @default.
- W2117746168 cites W2028439883 @default.
- W2117746168 cites W2034914625 @default.
- W2117746168 cites W2035949632 @default.
- W2117746168 cites W2036706643 @default.
- W2117746168 cites W2037521161 @default.
- W2117746168 cites W2039432504 @default.
- W2117746168 cites W2039760556 @default.
- W2117746168 cites W2041670760 @default.
- W2117746168 cites W2042711802 @default.
- W2117746168 cites W2043138008 @default.
- W2117746168 cites W2044773944 @default.
- W2117746168 cites W2050177211 @default.
- W2117746168 cites W2050679214 @default.
- W2117746168 cites W2052653818 @default.
- W2117746168 cites W2053816472 @default.
- W2117746168 cites W2054112982 @default.
- W2117746168 cites W2055123579 @default.
- W2117746168 cites W2056505906 @default.
- W2117746168 cites W2056893352 @default.
- W2117746168 cites W2056976690 @default.
- W2117746168 cites W2067853547 @default.
- W2117746168 cites W2074522672 @default.
- W2117746168 cites W2080745225 @default.
- W2117746168 cites W2083898560 @default.
- W2117746168 cites W2084130233 @default.
- W2117746168 cites W2089176098 @default.
- W2117746168 cites W2092389955 @default.
- W2117746168 cites W2097638191 @default.
- W2117746168 cites W2098780362 @default.
- W2117746168 cites W2106182986 @default.
- W2117746168 cites W2106244081 @default.
- W2117746168 cites W2107860946 @default.
- W2117746168 cites W2107914594 @default.
- W2117746168 cites W2116520916 @default.
- W2117746168 cites W2118174129 @default.
- W2117746168 cites W2118626367 @default.
- W2117746168 cites W2118735729 @default.
- W2117746168 cites W2119869567 @default.
- W2117746168 cites W2122088193 @default.
- W2117746168 cites W2124707947 @default.
- W2117746168 cites W2124737750 @default.
- W2117746168 cites W2125524254 @default.
- W2117746168 cites W2125943457 @default.
- W2117746168 cites W2126175185 @default.
- W2117746168 cites W2128843189 @default.
- W2117746168 cites W2129711762 @default.
- W2117746168 cites W2129902852 @default.
- W2117746168 cites W2129961336 @default.
- W2117746168 cites W2132397897 @default.
- W2117746168 cites W2135038122 @default.
- W2117746168 cites W2135136127 @default.
- W2117746168 cites W2135492024 @default.
- W2117746168 cites W2138670606 @default.
- W2117746168 cites W2138806344 @default.
- W2117746168 cites W2143144750 @default.
- W2117746168 cites W2144391460 @default.
- W2117746168 cites W2145461177 @default.
- W2117746168 cites W2147804563 @default.
- W2117746168 cites W2149197585 @default.
- W2117746168 cites W2152592072 @default.
- W2117746168 cites W2153027424 @default.
- W2117746168 cites W2156850243 @default.
- W2117746168 cites W2157382533 @default.
- W2117746168 cites W2160071918 @default.