FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117755788> ?p ?o ?g. }

• W2117755788 endingPage "8" @default.
• W2117755788 startingPage "1" @default.
• W2117755788 abstract "We have previously described an immortal rat central-nervous-system progenitor cell line, AF5, which is able to exit the cell cycle and assume a differentiated state with neuronal properties. The phenotypic specification of differentiated AF5 cells, however, is not known. In the present study, when induced to differentiate by serum starvation in Neurobasal medium, AF5 cells down-regulate glial fibrillary acidic protein and up-regulate expression of β–III–tubulin, medium-molecular-weight neurofilament protein, and neuronal growth-associated protein 43. Expression of the gamma-aminobutyric acid (GABA) lineage marker, glutamic acid decarboxylase 67 (GAD67), increases during differentiation, suggesting that AF5 cells adopt a GABAergic lineage. Time-course analysis of the GABAergic neuron specification transcription factor, Pitx2, by reverse transcription/polymerase chain reaction, has shown an increase in the Pitx2 transcript 48 h after initiation of differentiation. In differentiated AF5 cells, expression of the Pitx2 target gene products GAD65 and GABA transporter-1 increases. Cellular GABA levels in differentiated AF5 cells increase by about 26-fold, and GABA release into the medium is 150-fold higher compared with that of undifferentiated cells. Therefore, AF5 cells can be induced to differentiate to a neuronal phenotype with a GABAergic lineage." @default.
• W2117755788 created "2016-06-24" @default.
• W2117755788 creator A5009697908 @default.
• W2117755788 creator A5017316211 @default.
• W2117755788 creator A5024520512 @default.
• W2117755788 creator A5030688459 @default.
• W2117755788 creator A5033658367 @default.
• W2117755788 creator A5037616538 @default.
• W2117755788 creator A5040069212 @default.
• W2117755788 creator A5049419210 @default.
• W2117755788 creator A5068018680 @default.
• W2117755788 creator A5074940124 @default.
• W2117755788 creator A5086808779 @default.
• W2117755788 date "2006-01-12" @default.
• W2117755788 modified "2023-09-25" @default.
• W2117755788 title "GABAergic lineage differentiation of AF5 neural progenitor cells in vitro" @default.
• W2117755788 cites W1487720736 @default.
• W2117755788 cites W1535478329 @default.
• W2117755788 cites W1576110235 @default.
• W2117755788 cites W1598680760 @default.
• W2117755788 cites W176212822 @default.
• W2117755788 cites W1971033959 @default.
• W2117755788 cites W1977215237 @default.
• W2117755788 cites W1979712056 @default.
• W2117755788 cites W1983350277 @default.
• W2117755788 cites W1987107175 @default.
• W2117755788 cites W1995176369 @default.
• W2117755788 cites W2009430329 @default.
• W2117755788 cites W2017329102 @default.
• W2117755788 cites W2021429544 @default.
• W2117755788 cites W2032363591 @default.
• W2117755788 cites W2033410250 @default.
• W2117755788 cites W2040488994 @default.
• W2117755788 cites W2046450144 @default.
• W2117755788 cites W2068401443 @default.
• W2117755788 cites W2074668650 @default.
• W2117755788 cites W2076237842 @default.
• W2117755788 cites W2079585728 @default.
• W2117755788 cites W2088949976 @default.
• W2117755788 cites W2118474414 @default.
• W2117755788 cites W2131937765 @default.
• W2117755788 cites W2133960052 @default.
• W2117755788 cites W2141474963 @default.
• W2117755788 cites W2142766154 @default.
• W2117755788 cites W2143470407 @default.
• W2117755788 cites W2150817988 @default.
• W2117755788 cites W2153164431 @default.
• W2117755788 cites W2166687046 @default.
• W2117755788 cites W2316627051 @default.
• W2117755788 cites W2397611693 @default.
• W2117755788 cites W4246873777 @default.
• W2117755788 doi "https://doi.org/10.1007/s00441-005-0094-z" @default.
• W2117755788 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2673919" @default.
• W2117755788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16408195" @default.
• W2117755788 hasPublicationYear "2006" @default.
• W2117755788 type Work @default.
• W2117755788 sameAs 2117755788 @default.
• W2117755788 citedByCount "23" @default.
• W2117755788 countsByYear W21177557882012 @default.
• W2117755788 countsByYear W21177557882013 @default.
• W2117755788 countsByYear W21177557882014 @default.
• W2117755788 countsByYear W21177557882015 @default.
• W2117755788 countsByYear W21177557882018 @default.
• W2117755788 countsByYear W21177557882019 @default.
• W2117755788 countsByYear W21177557882021 @default.
• W2117755788 countsByYear W21177557882023 @default.
• W2117755788 crossrefType "journal-article" @default.
• W2117755788 hasAuthorship W2117755788A5009697908 @default.
• W2117755788 hasAuthorship W2117755788A5017316211 @default.
• W2117755788 hasAuthorship W2117755788A5024520512 @default.
• W2117755788 hasAuthorship W2117755788A5030688459 @default.
• W2117755788 hasAuthorship W2117755788A5033658367 @default.
• W2117755788 hasAuthorship W2117755788A5037616538 @default.
• W2117755788 hasAuthorship W2117755788A5040069212 @default.
• W2117755788 hasAuthorship W2117755788A5049419210 @default.
• W2117755788 hasAuthorship W2117755788A5068018680 @default.
• W2117755788 hasAuthorship W2117755788A5074940124 @default.
• W2117755788 hasAuthorship W2117755788A5086808779 @default.
• W2117755788 hasBestOaLocation W21177557882 @default.
• W2117755788 hasConcept C104317684 @default.
• W2117755788 hasConcept C148738053 @default.
• W2117755788 hasConcept C153911025 @default.
• W2117755788 hasConcept C15729860 @default.
• W2117755788 hasConcept C169760540 @default.
• W2117755788 hasConcept C17077164 @default.
• W2117755788 hasConcept C181199279 @default.
• W2117755788 hasConcept C201750760 @default.
• W2117755788 hasConcept C2779177108 @default.
• W2117755788 hasConcept C28328180 @default.
• W2117755788 hasConcept C54355233 @default.
• W2117755788 hasConcept C55493867 @default.
• W2117755788 hasConcept C86803240 @default.
• W2117755788 hasConcept C9497952 @default.
• W2117755788 hasConcept C95444343 @default.
• W2117755788 hasConceptScore W2117755788C104317684 @default.
• W2117755788 hasConceptScore W2117755788C148738053 @default.
• W2117755788 hasConceptScore W2117755788C153911025 @default.
• W2117755788 hasConceptScore W2117755788C15729860 @default.

• next