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- W2117776432 abstract "The structural basis for accurate placement of substrate RNA by H/ACA proteins is studied using a nonintrusive fluorescence assay. A model substrate RNA containing 2-aminopurine immediately 3' of the uridine targeted for modification produces distinct fluorescence signals that report the substrate's docking status within the enzyme active site. We combined substrate RNA with complete and subcomplexes of H/ACA ribonucleoprotein particles and monitored changes in the substrate conformation. Our results show that each of the three accessory proteins, as well as an active site residue, have distinct effects on substrate conformations, presumably as docking occurs. Interestingly, in some cases these effects are exerted far from the active site. Application of our data to an available structural model of the holoenzyme, enables the functional role of each accessory protein in substrate placement to come into view." @default.
- W2117776432 created "2016-06-24" @default.
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- W2117776432 date "2008-08-28" @default.
- W2117776432 modified "2023-10-14" @default.
- W2117776432 title "Long-distance placement of substrate RNA by H/ACA proteins" @default.
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- W2117776432 doi "https://doi.org/10.1261/rna.1109808" @default.
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