FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117781857> ?p ?o ?g. }

• W2117781857 endingPage "1082" @default.
• W2117781857 startingPage "1073" @default.
• W2117781857 abstract "During in vitro maturation of porcine cumulus-oocyte complexes (COCs), follicle-stimulating hormone (FSH) increases both prostaglandin E2 (PGE2) production and the expression levels of EGF-like factors. The ligands act on cumulus cells by the autocrine system due to their specific receptors, EP2, EP4, or EGF receptor. When each pathway is suppressed by inhibitors, complete cumulus expansion and oocyte maturation do not occur. In this study, we examined the relationship between both of these pathways in cumulus cells of porcine COCs. When COCs were cultured with FSH, Fshr mRNA expression was immediately decreased within 5 h, whereas Ptger2, Ptger4, and Ptgs2 expression levels were significantly increased in cumulus cells in the culture containing FSH for 5 or 10 h. The PTGS2 inhibitor NS398 significantly suppressed not only PGE2 secretion at any culture time point but also Areg, Ereg, and Tace/Adam17 expression in cumulus cells at 10 and 20 h but not at 1 or 5 h. During the early culture period, phosphorylation of MAPK3 and MAPK1 (MAPK3/1) was not affected by NS398; however, at 10 and 20 h, phosphorylation was suppressed by the drug. Furthermore, down-regulations of MAPK3/1 phosphorylation and expression of the target genes by NS398 was overcome by the addition of either PGE2 or EGF. FSH-induced cumulus expansion and meiotic progression to the MII stage were also suppressed by NS398, whereas these effects were also overcome by addition of either PGE2 or EGF. These results indicated that PGE2 is involved in the sustainable activation of MAPK3/1 in cumulus cells via the induction of EGF-like factor, which is required for cumulus expansion and meiotic maturation of porcine COCs." @default.
• W2117781857 created "2016-06-24" @default.
• W2117781857 creator A5014604553 @default.
• W2117781857 creator A5043033233 @default.
• W2117781857 creator A5043428080 @default.
• W2117781857 creator A5044990593 @default.
• W2117781857 creator A5050737789 @default.
• W2117781857 creator A5069748221 @default.
• W2117781857 creator A5073081765 @default.
• W2117781857 creator A5086925809 @default.
• W2117781857 date "2011-11-01" @default.
• W2117781857 modified "2023-10-05" @default.
• W2117781857 title "Positive Feedback Loop Between Prostaglandin E2 and EGF-Like Factors Is Essential for Sustainable Activation of MAPK3/1 in Cumulus Cells During In Vitro Maturation of Porcine Cumulus Oocyte Complexes1" @default.
• W2117781857 cites W1980489970 @default.
• W2117781857 cites W1987092404 @default.
• W2117781857 cites W1987945086 @default.
• W2117781857 cites W1990375473 @default.
• W2117781857 cites W1995657296 @default.
• W2117781857 cites W2008015660 @default.
• W2117781857 cites W2015476509 @default.
• W2117781857 cites W2017234272 @default.
• W2117781857 cites W2019502908 @default.
• W2117781857 cites W2030456407 @default.
• W2117781857 cites W2036457263 @default.
• W2117781857 cites W2041655797 @default.
• W2117781857 cites W2055066843 @default.
• W2117781857 cites W2063439993 @default.
• W2117781857 cites W2080969081 @default.
• W2117781857 cites W2084172300 @default.
• W2117781857 cites W2093740859 @default.
• W2117781857 cites W2103625501 @default.
• W2117781857 cites W2113780564 @default.
• W2117781857 cites W2114367399 @default.
• W2117781857 cites W2121612337 @default.
• W2117781857 cites W2145855314 @default.
• W2117781857 cites W2149342062 @default.
• W2117781857 cites W2150679731 @default.
• W2117781857 cites W2161581656 @default.
• W2117781857 cites W2168869412 @default.
• W2117781857 doi "https://doi.org/10.1095/biolreprod.110.090092" @default.
• W2117781857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21778143" @default.
• W2117781857 hasPublicationYear "2011" @default.
• W2117781857 type Work @default.
• W2117781857 sameAs 2117781857 @default.
• W2117781857 citedByCount "31" @default.
• W2117781857 countsByYear W21177818572013 @default.
• W2117781857 countsByYear W21177818572014 @default.
• W2117781857 countsByYear W21177818572015 @default.
• W2117781857 countsByYear W21177818572016 @default.
• W2117781857 countsByYear W21177818572017 @default.
• W2117781857 countsByYear W21177818572018 @default.
• W2117781857 countsByYear W21177818572019 @default.
• W2117781857 countsByYear W21177818572020 @default.
• W2117781857 countsByYear W21177818572021 @default.
• W2117781857 countsByYear W21177818572022 @default.
• W2117781857 crossrefType "journal-article" @default.
• W2117781857 hasAuthorship W2117781857A5014604553 @default.
• W2117781857 hasAuthorship W2117781857A5043033233 @default.
• W2117781857 hasAuthorship W2117781857A5043428080 @default.
• W2117781857 hasAuthorship W2117781857A5044990593 @default.
• W2117781857 hasAuthorship W2117781857A5050737789 @default.
• W2117781857 hasAuthorship W2117781857A5069748221 @default.
• W2117781857 hasAuthorship W2117781857A5073081765 @default.
• W2117781857 hasAuthorship W2117781857A5086925809 @default.
• W2117781857 hasBestOaLocation W21177818571 @default.
• W2117781857 hasConcept C126322002 @default.
• W2117781857 hasConcept C128240485 @default.
• W2117781857 hasConcept C134018914 @default.
• W2117781857 hasConcept C16685009 @default.
• W2117781857 hasConcept C170493617 @default.
• W2117781857 hasConcept C196843134 @default.
• W2117781857 hasConcept C2775966511 @default.
• W2117781857 hasConcept C2776690073 @default.
• W2117781857 hasConcept C2777956040 @default.
• W2117781857 hasConcept C2778928357 @default.
• W2117781857 hasConcept C5512455 @default.
• W2117781857 hasConcept C55493867 @default.
• W2117781857 hasConcept C71924100 @default.
• W2117781857 hasConcept C86803240 @default.
• W2117781857 hasConcept C87073359 @default.
• W2117781857 hasConcept C95444343 @default.
• W2117781857 hasConceptScore W2117781857C126322002 @default.
• W2117781857 hasConceptScore W2117781857C128240485 @default.
• W2117781857 hasConceptScore W2117781857C134018914 @default.
• W2117781857 hasConceptScore W2117781857C16685009 @default.
• W2117781857 hasConceptScore W2117781857C170493617 @default.
• W2117781857 hasConceptScore W2117781857C196843134 @default.
• W2117781857 hasConceptScore W2117781857C2775966511 @default.
• W2117781857 hasConceptScore W2117781857C2776690073 @default.
• W2117781857 hasConceptScore W2117781857C2777956040 @default.
• W2117781857 hasConceptScore W2117781857C2778928357 @default.
• W2117781857 hasConceptScore W2117781857C5512455 @default.
• W2117781857 hasConceptScore W2117781857C55493867 @default.
• W2117781857 hasConceptScore W2117781857C71924100 @default.
• W2117781857 hasConceptScore W2117781857C86803240 @default.
• W2117781857 hasConceptScore W2117781857C87073359 @default.
• W2117781857 hasConceptScore W2117781857C95444343 @default.
• W2117781857 hasIssue "5" @default.

• next