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• W2117782092 abstract "ABSTRACT Some Listeria monocytogenes internalins are recognized as contributing to invasion of mammalian tissue culture cells. While PrfA is well established as a positive regulator of L. monocytogenes virulence gene expression, the stress-responsive σ B has been recognized only recently as contributing to expression of virulence genes, including some that encode internalins. To measure the relative contributions of PrfA and σ B to internalin gene transcription, we used reverse transcription-PCR to quantify transcript levels for eight internalin genes ( inlA, inlB, inlC, inlC2, inlD, inlE, inlF , and inlG ) in L. monocytogenes 10403S and in isogenic Δ prfA , Δ sigB , and Δ sigB Δ prfA strains. Strains were grown under defined conditions to produce (i) active PrfA, (ii) active σ B and active PrfA, (iii) inactive PrfA, and (iv) active σ B and inactive PrfA. Under the conditions tested, σ B and PrfA contributed differentially to the expression of the various internalins such that (i) both σ B and PrfA contributed to inlA and inlB transcription, (ii) only PrfA contributed to inlC transcription, (iii) only σ B contributed to inlC2 and inlD transcription, and (iv) neither σ B nor PrfA contributed to inlF and inlG transcription. inlE transcript levels were undetectable. The important role for σ B in regulating expression of L. monocytogenes internalins suggests that exposure of this organism to environmental stress conditions, such as those encountered in the gastrointestinal tract, may activate internalin transcription. Interplay between σ B and PrfA also appears to be critical for regulating transcription of some virulence genes, including inlA, inlB , and prfA ." @default.
• W2117782092 created "2016-06-24" @default.
• W2117782092 creator A5033699998 @default.
• W2117782092 creator A5062868312 @default.
• W2117782092 creator A5082217142 @default.
• W2117782092 date "2007-05-01" @default.
• W2117782092 modified "2023-10-18" @default.
• W2117782092 title "The Alternative Sigma Factor σ^Band the Virulence Gene Regulator PrfA Both Regulate Transcription of<i>Listeria monocytogenes</i>Internalins" @default.
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• W2117782092 doi "https://doi.org/10.1128/aem.02664-06" @default.
• W2117782092 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1892873" @default.
• W2117782092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17337550" @default.
• W2117782092 hasPublicationYear "2007" @default.
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