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- W2117783469 abstract "The chemical modification of bacterial components was studied following incubation of Escherichia coli with the peroxidase-hydrogen peroxide (H 2 O 2 )-iodide (I − ) antimicrobial system or with iodine (I 2 ). The oxidation of cell sulfhydryls and the iodination of cell components were measured. Both the peroxidase system and I 2 oxidized sulfhydryls. When the I − concentration in the peroxidase system was greater than 100 μM, the peroxidase system and I 2 were equivalent. That is, sulfhydryl oxidation or killing per mole of H 2 O 2 equaled that per mole of I 2 . These results were consistent with peroxidase-catalyzed oxidation of I − to yield 1 mol of I 2 per mol of H 2 O 2 . Sulfhydryls were oxidized to yield sulfenic acids and free I − . With I − concentrations in the range of 10 to 100 μM, the amount of sulfhydryls oxidized by the peroxidase system could exceed the amount of I − . Because the oxidation of sulfhydryls to sulfenic acids did not consume I − , one I − ion could participate in the oxidation of many sulfhydryls. With I − concentrations lower than 10 μM, complete oxidation of sulfhydryls was not obtained. Incorporation of I − into iodinated derivatives of bacterial components partly depleted the system of I − and limited the formation of I 2 . These results indicated that antimicrobial activity was due to peroxidase-catalyzed oxidation of I − to I 2 , followed by I 2 oxidation of cell components. There was a direct relationship between sulfhydryl oxidation and antimicrobial action. Although iodination of bacterial components accompanied sulfhydryl oxidation, the amount of I − incorporation was not directly related to antimicrobial action. Also, incorporation of I − interfered with antimicrobial action at low I − concentrations." @default.
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- W2117783469 title "Oxidation of <i>Escherichia coli</i> Sulfhydryl Components by the Peroxidase-Hydrogen Peroxide-Iodide Antimicrobial System" @default.
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- W2117783469 doi "https://doi.org/10.1128/aac.13.6.1006" @default.
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