Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117789426> ?p ?o ?g. }
- W2117789426 endingPage "234" @default.
- W2117789426 startingPage "229" @default.
- W2117789426 abstract "The cleavage model for signal transduction by receptors of the LIN-12/Notch family posits that ligand binding leads to cleavage within the transmembrane domain, so that the intracellular domain is released to translocate to the nucleus and activate target gene expression. The familial Alzheimer's disease-associated protein Presenilin is required for LIN-12/Notch signaling, and several lines of evidence suggest that Presenilin mediates the transmembrane cleavage event that releases the LIN-12/Notch intracellular domain. However, doubt was cast on this possibility by a report that Presenilin is not required for the transducing activity of N ECN , a constitutively active transmembrane form of Notch, in Drosophila . Here, we have reassessed this finding and show instead that Presenilin is required for activity of N ECN for all cell fate decisions examined. Our results indicate that transmembrane cleavage and signal transduction are strictly correlated, supporting the cleavage model for signal transduction by LIN-12/Notch and a role for Presenilin in mediating the ligand-induced transmembrane cleavage." @default.
- W2117789426 created "2016-06-24" @default.
- W2117789426 creator A5069328543 @default.
- W2117789426 creator A5084912092 @default.
- W2117789426 date "2000-12-26" @default.
- W2117789426 modified "2023-09-27" @default.
- W2117789426 title "Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in <i>Drosophila</i>" @default.
- W2117789426 cites W1480987708 @default.
- W2117789426 cites W1524261859 @default.
- W2117789426 cites W1595935608 @default.
- W2117789426 cites W1655397332 @default.
- W2117789426 cites W1655404681 @default.
- W2117789426 cites W1660631781 @default.
- W2117789426 cites W1675105744 @default.
- W2117789426 cites W1971753759 @default.
- W2117789426 cites W1971855104 @default.
- W2117789426 cites W1979432217 @default.
- W2117789426 cites W1984752460 @default.
- W2117789426 cites W1995434077 @default.
- W2117789426 cites W1995650022 @default.
- W2117789426 cites W1998451680 @default.
- W2117789426 cites W2000550532 @default.
- W2117789426 cites W2006229889 @default.
- W2117789426 cites W2016668224 @default.
- W2117789426 cites W2019007505 @default.
- W2117789426 cites W2027128159 @default.
- W2117789426 cites W2029307548 @default.
- W2117789426 cites W2061738087 @default.
- W2117789426 cites W2063733034 @default.
- W2117789426 cites W2066877759 @default.
- W2117789426 cites W2082195162 @default.
- W2117789426 cites W2092034939 @default.
- W2117789426 cites W2098503611 @default.
- W2117789426 cites W2108320273 @default.
- W2117789426 cites W2109638112 @default.
- W2117789426 cites W2110643873 @default.
- W2117789426 cites W2120304489 @default.
- W2117789426 cites W2129092300 @default.
- W2117789426 cites W2149008219 @default.
- W2117789426 cites W2153311182 @default.
- W2117789426 cites W2156910937 @default.
- W2117789426 cites W2157739471 @default.
- W2117789426 cites W2164898869 @default.
- W2117789426 cites W2775777157 @default.
- W2117789426 cites W2833026885 @default.
- W2117789426 cites W2892692795 @default.
- W2117789426 doi "https://doi.org/10.1073/pnas.98.1.229" @default.
- W2117789426 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/14573" @default.
- W2117789426 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11134525" @default.
- W2117789426 hasPublicationYear "2000" @default.
- W2117789426 type Work @default.
- W2117789426 sameAs 2117789426 @default.
- W2117789426 citedByCount "115" @default.
- W2117789426 countsByYear W21177894262012 @default.
- W2117789426 countsByYear W21177894262013 @default.
- W2117789426 countsByYear W21177894262014 @default.
- W2117789426 countsByYear W21177894262015 @default.
- W2117789426 countsByYear W21177894262016 @default.
- W2117789426 countsByYear W21177894262017 @default.
- W2117789426 countsByYear W21177894262019 @default.
- W2117789426 countsByYear W21177894262020 @default.
- W2117789426 countsByYear W21177894262021 @default.
- W2117789426 countsByYear W21177894262022 @default.
- W2117789426 countsByYear W21177894262023 @default.
- W2117789426 crossrefType "journal-article" @default.
- W2117789426 hasAuthorship W2117789426A5069328543 @default.
- W2117789426 hasAuthorship W2117789426A5084912092 @default.
- W2117789426 hasBestOaLocation W21177894262 @default.
- W2117789426 hasConcept C118892022 @default.
- W2117789426 hasConcept C126322002 @default.
- W2117789426 hasConcept C151730666 @default.
- W2117789426 hasConcept C161879069 @default.
- W2117789426 hasConcept C170493617 @default.
- W2117789426 hasConcept C175156509 @default.
- W2117789426 hasConcept C175344181 @default.
- W2117789426 hasConcept C202769670 @default.
- W2117789426 hasConcept C24530287 @default.
- W2117789426 hasConcept C2779134260 @default.
- W2117789426 hasConcept C43369102 @default.
- W2117789426 hasConcept C502032728 @default.
- W2117789426 hasConcept C54355233 @default.
- W2117789426 hasConcept C62478195 @default.
- W2117789426 hasConcept C65114990 @default.
- W2117789426 hasConcept C71924100 @default.
- W2117789426 hasConcept C79879829 @default.
- W2117789426 hasConcept C86803240 @default.
- W2117789426 hasConcept C95444343 @default.
- W2117789426 hasConceptScore W2117789426C118892022 @default.
- W2117789426 hasConceptScore W2117789426C126322002 @default.
- W2117789426 hasConceptScore W2117789426C151730666 @default.
- W2117789426 hasConceptScore W2117789426C161879069 @default.
- W2117789426 hasConceptScore W2117789426C170493617 @default.
- W2117789426 hasConceptScore W2117789426C175156509 @default.
- W2117789426 hasConceptScore W2117789426C175344181 @default.
- W2117789426 hasConceptScore W2117789426C202769670 @default.
- W2117789426 hasConceptScore W2117789426C24530287 @default.
- W2117789426 hasConceptScore W2117789426C2779134260 @default.
- W2117789426 hasConceptScore W2117789426C43369102 @default.