FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2117795053> ?p ?o ?g. }

• W2117795053 endingPage "9223" @default.
• W2117795053 startingPage "9217" @default.
• W2117795053 abstract "Microtubules are cytoskeleton multifilament proteins that support many fundamental biological processes such as cell division, cellular transport, and motility. They can be viewed as dynamic polymers that function in nonequilibrium conditions stimulated by hydrolysis of GTP (guanosine triphosphate) molecules bound to their monomers. We present a theoretical description of microtubule dynamics based on discrete-state stochastic models that explicitly takes into account all relevant biochemical transitions. In contrast to previous theoretical analysis, a more realistic physical-chemical description of GTP hydrolysis is presented, in which the hydrolysis rate at a given monomer depends on the chemical composition of the neighboring monomers. This dependence naturally leads to a cooperativity in the hydrolysis. It is found that this cooperativity significantly influences all dynamic properties of microtubules. It is suggested that the dynamic instability in cytoskeleton proteins might be observed only for weak cooperativity, while the strong cooperativity in hydrolysis suppresses the dynamic instability. The presented microscopic analysis is compared with existing phenomenological descriptions of hydrolysis processes. Our analytical calculations, supported by computer Monte Carlo simulations, are also compared with available experimental observations." @default.
• W2117795053 created "2016-06-24" @default.
• W2117795053 creator A5029187622 @default.
• W2117795053 creator A5040071198 @default.
• W2117795053 date "2013-07-30" @default.
• W2117795053 modified "2023-10-18" @default.
• W2117795053 title "Theoretical Analysis of Microtubules Dynamics Using a Physical–Chemical Description of Hydrolysis" @default.
• W2117795053 cites W1965151798 @default.
• W2117795053 cites W1965404941 @default.
• W2117795053 cites W1973530331 @default.
• W2117795053 cites W1974424751 @default.
• W2117795053 cites W1976630991 @default.
• W2117795053 cites W1982746676 @default.
• W2117795053 cites W1994336523 @default.
• W2117795053 cites W2004324575 @default.
• W2117795053 cites W2012486944 @default.
• W2117795053 cites W2028905487 @default.
• W2117795053 cites W2034885034 @default.
• W2117795053 cites W2041158925 @default.
• W2117795053 cites W2042515129 @default.
• W2117795053 cites W2049148686 @default.
• W2117795053 cites W2063282276 @default.
• W2117795053 cites W2069097627 @default.
• W2117795053 cites W2069274752 @default.
• W2117795053 cites W2071782313 @default.
• W2117795053 cites W2072034848 @default.
• W2117795053 cites W2073153669 @default.
• W2117795053 cites W2082431242 @default.
• W2117795053 cites W2089843126 @default.
• W2117795053 cites W2108570298 @default.
• W2117795053 cites W2123387879 @default.
• W2117795053 cites W2129411210 @default.
• W2117795053 cites W2133743025 @default.
• W2117795053 cites W2146453988 @default.
• W2117795053 cites W2156684369 @default.
• W2117795053 cites W2157319245 @default.
• W2117795053 cites W2164560731 @default.
• W2117795053 cites W2171168835 @default.
• W2117795053 cites W2171219367 @default.
• W2117795053 cites W3100131606 @default.
• W2117795053 doi "https://doi.org/10.1021/jp404794f" @default.
• W2117795053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23844777" @default.
• W2117795053 hasPublicationYear "2013" @default.
• W2117795053 type Work @default.
• W2117795053 sameAs 2117795053 @default.
• W2117795053 citedByCount "9" @default.
• W2117795053 countsByYear W21177950532014 @default.
• W2117795053 countsByYear W21177950532015 @default.
• W2117795053 countsByYear W21177950532017 @default.
• W2117795053 countsByYear W21177950532019 @default.
• W2117795053 countsByYear W21177950532020 @default.
• W2117795053 crossrefType "journal-article" @default.
• W2117795053 hasAuthorship W2117795053A5029187622 @default.
• W2117795053 hasAuthorship W2117795053A5040071198 @default.
• W2117795053 hasConcept C121332964 @default.
• W2117795053 hasConcept C121864883 @default.
• W2117795053 hasConcept C147597530 @default.
• W2117795053 hasConcept C159467904 @default.
• W2117795053 hasConcept C166014724 @default.
• W2117795053 hasConcept C166940927 @default.
• W2117795053 hasConcept C178790620 @default.
• W2117795053 hasConcept C185592680 @default.
• W2117795053 hasConcept C20418707 @default.
• W2117795053 hasConcept C49852136 @default.
• W2117795053 hasConcept C521977710 @default.
• W2117795053 hasConcept C55493867 @default.
• W2117795053 hasConcept C86803240 @default.
• W2117795053 hasConcept C95444343 @default.
• W2117795053 hasConceptScore W2117795053C121332964 @default.
• W2117795053 hasConceptScore W2117795053C121864883 @default.
• W2117795053 hasConceptScore W2117795053C147597530 @default.
• W2117795053 hasConceptScore W2117795053C159467904 @default.
• W2117795053 hasConceptScore W2117795053C166014724 @default.
• W2117795053 hasConceptScore W2117795053C166940927 @default.
• W2117795053 hasConceptScore W2117795053C178790620 @default.
• W2117795053 hasConceptScore W2117795053C185592680 @default.
• W2117795053 hasConceptScore W2117795053C20418707 @default.
• W2117795053 hasConceptScore W2117795053C49852136 @default.
• W2117795053 hasConceptScore W2117795053C521977710 @default.
• W2117795053 hasConceptScore W2117795053C55493867 @default.
• W2117795053 hasConceptScore W2117795053C86803240 @default.
• W2117795053 hasConceptScore W2117795053C95444343 @default.
• W2117795053 hasIssue "31" @default.
• W2117795053 hasLocation W21177950531 @default.
• W2117795053 hasLocation W21177950532 @default.
• W2117795053 hasOpenAccess W2117795053 @default.
• W2117795053 hasPrimaryLocation W21177950531 @default.
• W2117795053 hasRelatedWork W2011484343 @default.
• W2117795053 hasRelatedWork W2057337811 @default.
• W2117795053 hasRelatedWork W2090786201 @default.
• W2117795053 hasRelatedWork W2093011275 @default.
• W2117795053 hasRelatedWork W2102116041 @default.
• W2117795053 hasRelatedWork W2769066625 @default.
• W2117795053 hasRelatedWork W2886156086 @default.
• W2117795053 hasRelatedWork W2943319320 @default.
• W2117795053 hasRelatedWork W3034522448 @default.
• W2117795053 hasRelatedWork W4361190986 @default.
• W2117795053 hasVolume "117" @default.

• next