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- W2117795410 abstract "Single retinal ganglion cell’s (RGC) response properties, such as spike count and response latency, are known to encode some features of visual stimuli. On the other hand, neuronal response can be modulated by dopamine (DA), an important endogenous neuromodulator in the retina. In the present study, we investigated the effects of DA on the spike count and the response latency of bullfrog ON-OFF RGCs during exposure to different stimulus durations. We found that neuronal spike count and response latency were both changed with stimulus durations, and exogenous DA (10 μM) obviously attenuated the stimulus-duration-dependent response latency change. Information analysis showed that the information about light ON duration was mainly carried by the OFF response and vice versa, and the stimulation information was carried by both spike count and response latency. However, during DA application, the information carried by the response latency was greatly decreased, which suggests that dopaminergic pathway is involved in modulating the role of response latency in encoding the information about stimulus durations." @default.
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- W2117795410 date "2014-06-30" @default.
- W2117795410 modified "2023-10-18" @default.
- W2117795410 title "Effects of dopamine on response properties of ON-OFF RGCs in encoding stimulus durations" @default.
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- W2117795410 doi "https://doi.org/10.3389/fncir.2014.00072" @default.
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